Luca Pinzi

Affiliations

Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, via Campi 103, 41125, Modena, Italy.

Publications (31)

2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B.

ChemMedChem

Avec: Maria L Di Paolo , Michael S Christodoulou , Alessandra M Calogero , Luca Pinzi , Giulio Rastelli , Daniele Passarella , Graziella Cappelletti , Lisa Dalla Via

Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications.

ACS omega

Avec: Andrea Citarella , Davide Moi , Luca Pinzi , Davide Bonanni , Giulio Rastelli

Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.

European journal of medicinal chemistry

Avec: Annachiara Tinivella , Jerome C Nwachukwu , Andrea Angeli , Francesca Foschi , Anna Laura Benatti , Luca Pinzi , Tina Izard , Marta Ferraroni , Rangarajan Erumbi , Michael S Christodoulou , Daniele Passarella , Claudiu T Supuran , Kendall W Nettles , Giulio Rastelli

Repositioning Natural Products in Drug Discovery.

Molecules (Basel, Switzerland)

Avec: Giulio Rastelli , Federica Pellati , Luca Pinzi , Maria Cristina Gamberini

In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA).

Molecules (Basel, Switzerland)

Avec: Luca Pinzi , Christian Lherbet , Michel Baltas , Federica Pellati , Giulio Rastelli

Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group.

Journal of enzyme inhibition and medicinal chemistry

Avec: Pasquale Linciano , Luca Pinzi , Silvia Belluti , Ugo Chianese , Rosaria Benedetti , Davide Moi , Lucia Altucci , Silvia Franchini , Carol Imbriano , Claudia Sorbi , Giulio Rastelli

Drug Repurposing and Polypharmacology to Fight SARS-CoV-2 Through Inhibition of the Main Protease.

Frontiers in pharmacology

Avec: Luca Pinzi , Annachiara Tinivella , Fabiana Caporuscio , Giulio Rastelli

Prediction of activity and selectivity profiles of human Carbonic Anhydrase inhibitors using machine learning classification models.

Journal of cheminformatics

Avec: Annachiara Tinivella , Luca Pinzi , Giulio Rastelli

Chemoinformatics Analyses of Tau Ligands Reveal Key Molecular Requirements for the Identification of Potential Drug Candidates against Tauopathies.

Molecules (Basel, Switzerland)

Avec: Luca Pinzi , Annachiara Tinivella , Giulio Rastelli

Trends and Applications in Computationally Driven Drug Repurposing.

International journal of molecular sciences

Avec: Luca Pinzi , Giulio Rastelli

Refinement and Rescoring of Virtual Screening Results.

Frontiers in chemistry

Avec: Giulio Rastelli , Luca Pinzi

Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5.

Journal of medicinal chemistry

Avec: Davide Graziani , Silvia Caligari , Elisa Callegari , Carlo De Toma , Matteo Longhi , Fabio Frigerio , Roberto Dilernia , Sergio Menegon , Luca Pinzi , Lorenza Pirona , Valerio Tazzari , Anna Elisa Valsecchi , Giulio Vistoli , Giulio Rastelli , Carlo Riva

Molecular Docking: Shifting Paradigms in Drug Discovery.

International journal of molecular sciences

Avec: Luca Pinzi , Giulio Rastelli

Design of Dual Inhibitors of Histone Deacetylase 6 and Heat Shock Protein 90.

ACS omega

Avec: Luca Pinzi , Rosaria Benedetti , Lucia Altucci , Giulio Rastelli

Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90).

Current medicinal chemistry

Avec: Davide Bonanni , Andrea Citarella , Davide Moi , Luca Pinzi , Elisa Bergamini , Giulio Rastelli

Development of machine learning classifiers to predict compound activity on prostate cancer cell lines.

Journal of cheminformatics

Avec: Davide Bonanni , Luca Pinzi , Giulio Rastelli

Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR.

Journal of enzyme inhibition and medicinal chemistry

Avec: Francesca Foschi , Annachiara Tinivella , Valentina Crippa , Luca Pinzi , Luca Mologni , Daniele Passarella , Giulio Rastelli

Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer.

European journal of medicinal chemistry

Avec: Davide Moi , Davide Bonanni , Silvia Belluti , Pasquale Linciano , Andrea Citarella , Silvia Franchini , Claudia Sorbi , Carol Imbriano , Luca Pinzi , Giulio Rastelli

Identification of Target Associations for Polypharmacology from Analysis of Crystallographic Ligands of the Protein Data Bank.

Journal of chemical information and modeling

Avec: Luca Pinzi , Giulio Rastelli

Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B.

ACS medicinal chemistry letters

Avec: Luca G Iacovino , Luca Pinzi , Giorgio Facchetti , Beatrice Bortolini , Michael S Christodoulou , Claudia Binda , Giulio Rastelli , Isabella Rimoldi , Daniele Passarella , Maria Luisa Di Paolo , Lisa Dalla Via

Design and Synthesis of Hsp90 Inhibitors with B-Raf and PDHK1 Multi-Target Activity.

ChemistryOpen

Avec: Luca Pinzi , Francesca Foschi , Michael S Christodoulou , Daniele Passarella , Giulio Rastelli

On the development of B-Raf inhibitors acting through innovative mechanisms.

F1000Research

Avec: Luca Pinzi

Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction.

Nature communications

Avec: Luca Pinzi , Christian Conze , Nicolo Bisi , Gabriele Dalla Torre , Ahmed Soliman , Nanci Monteiro-Abreu , Nataliya I Trushina , Andrea Krusenbaum , Maryam Khodaei Dolouei , Andrea Hellwig , Michael S Christodoulou , Daniele Passarella , Lidia Bakota , Giulio Rastelli , Roland Brandt

Searching for Novel HDAC6/Hsp90 Dual Inhibitors with Anti-Prostate Cancer Activity: In Silico Screening and In Vitro Evaluation.

Pharmaceuticals (Basel, Switzerland)

Avec: Luca Pinzi , Silvia Belluti , Isabella Piccinini , Carol Imbriano , Giulio Rastelli

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.

Molecules (Basel, Switzerland)

Avec: Luca Pinzi , Nicolò Bisi , Claudia Sorbi , Silvia Franchini , Nicolò Tonali , Giulio Rastelli

Early Diagnosis of Neurodegenerative Diseases: What Has Been Undertaken to Promote the Transition from PET to Fluorescence Tracers.

Molecules (Basel, Switzerland)

Avec: Nicolò Bisi , Luca Pinzi , Giulio Rastelli , Nicolò Tonali

Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs).

Bioorganic chemistry

Avec: Pasquale Linciano , Rosaria Benedetti , Luca Pinzi , Fabiana Russo , Ugo Chianese , Claudia Sorbi , Lucia Altucci , Giulio Rastelli , Livio Brasili , Silvia Franchini

LigAdvisor: a versatile and user-friendly web-platform for drug design.

Nucleic acids research

Avec: Luca Pinzi , Annachiara Tinivella , Luca Gagliardelli , Domenico Beneventano , Giulio Rastelli

Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring.

RSC advances

Avec: Davide Moi , Andrea Citarella , Davide Bonanni , Luca Pinzi , Daniele Passarella , Alessandra Silvani , Clelia Giannini , Giulio Rastelli

Identification of Promising Drug Candidates against Prostate Cancer through Computationally-Driven Drug Repurposing.

International journal of molecular sciences

Avec: Leonardo Bernal , Luca Pinzi , Giulio Rastelli

Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase.

ACS pharmacology & translational science

Avec: Annachiara Tinivella , Marta Banchi , Guido Gambacorta , Federica Borghi , Paola Orlandi , Ian R Baxendale , Antonello Di Paolo , Guido Bocci , Luca Pinzi , Giulio Rastelli

Réseau de co-auteurs

Giulio Rastelli 30 collaborations

Daniele Passarella 7 collaborations

Annachiara Tinivella 7 collaborations

Michael S Christodoulou 5 collaborations

Davide Moi 5 collaborations

Davide Bonanni 5 collaborations

Andrea Citarella 4 collaborations

Silvia Franchini 4 collaborations

Claudia Sorbi 4 collaborations

Francesca Foschi 3 collaborations

Pasquale Linciano 3 collaborations

Silvia Belluti 3 collaborations

Rosaria Benedetti 3 collaborations

Lucia Altucci 3 collaborations

Carol Imbriano 3 collaborations

Lisa Dalla Via 2 collaborations

Federica Pellati 2 collaborations

Ugo Chianese 2 collaborations

Nicolò Bisi 2 collaborations

Nicolò Tonali 2 collaborations

Maria L Di Paolo 1 collaboration

Alessandra M Calogero 1 collaboration

Graziella Cappelletti 1 collaboration

Jerome C Nwachukwu 1 collaboration

Andrea Angeli 1 collaboration

Anna Laura Benatti 1 collaboration

Tina Izard 1 collaboration

Marta Ferraroni 1 collaboration

Rangarajan Erumbi 1 collaboration

Claudiu T Supuran 1 collaboration

Kendall W Nettles 1 collaboration

Maria Cristina Gamberini 1 collaboration

Christian Lherbet 1 collaboration

Michel Baltas 1 collaboration

Fabiana Caporuscio 1 collaboration

Davide Graziani 1 collaboration

Silvia Caligari 1 collaboration

Elisa Callegari 1 collaboration

Carlo De Toma 1 collaboration

Matteo Longhi 1 collaboration

Fabio Frigerio 1 collaboration

Roberto Dilernia 1 collaboration

Sergio Menegon 1 collaboration

Lorenza Pirona 1 collaboration

Valerio Tazzari 1 collaboration

Anna Elisa Valsecchi 1 collaboration

Giulio Vistoli 1 collaboration

Carlo Riva 1 collaboration

Elisa Bergamini 1 collaboration

Valentina Crippa 1 collaboration

Luca Mologni 1 collaboration

Luca G Iacovino 1 collaboration

Giorgio Facchetti 1 collaboration

Beatrice Bortolini 1 collaboration

Claudia Binda 1 collaboration

Isabella Rimoldi 1 collaboration

Maria Luisa Di Paolo 1 collaboration

Christian Conze 1 collaboration

Nicolo Bisi 1 collaboration

Gabriele Dalla Torre 1 collaboration

Ahmed Soliman 1 collaboration

Nanci Monteiro-Abreu 1 collaboration

Nataliya I Trushina 1 collaboration

Andrea Krusenbaum 1 collaboration

Maryam Khodaei Dolouei 1 collaboration

Andrea Hellwig 1 collaboration

Lidia Bakota 1 collaboration

Roland Brandt 1 collaboration

Isabella Piccinini 1 collaboration

Fabiana Russo 1 collaboration

Livio Brasili 1 collaboration

Luca Gagliardelli 1 collaboration

Domenico Beneventano 1 collaboration

Alessandra Silvani 1 collaboration

Clelia Giannini 1 collaboration

Leonardo Bernal 1 collaboration

Marta Banchi 1 collaboration

Guido Gambacorta 1 collaboration

Federica Borghi 1 collaboration

Paola Orlandi 1 collaboration

Ian R Baxendale 1 collaboration

Antonello Di Paolo 1 collaboration

Guido Bocci 1 collaboration