Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group.
HDAC inhibitors
HDAC6 inhibition
drug design
zinc-binding-group
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
29
9
2021
pubmed:
30
9
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HDAC6 inhibitors based on a completely new 3-hydroxy-isoxazole ZBG. A series of derivatives decorated with different aromatic or heteroaromatic linkers, and various cap groups were synthesised and biologically tested.
Identifiants
pubmed: 34583596
doi: 10.1080/14756366.2021.1981306
pmc: PMC8480759
doi:
Substances chimiques
Coordination Complexes
0
Histone Deacetylase Inhibitors
0
HDAC6 protein, human
EC 3.5.1.98
Histone Deacetylase 6
EC 3.5.1.98
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2080-2086Références
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