Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells.
Animals
Antineoplastic Agents
/ chemical synthesis
Carbocyanines
/ chemistry
Cell Line, Tumor
Dasatinib
/ chemical synthesis
Drug Design
Female
Fluorescent Dyes
/ chemical synthesis
Glioblastoma
/ drug therapy
Humans
Indoles
/ chemical synthesis
Mice, Nude
Protein Kinase Inhibitors
/ chemical synthesis
Theranostic Nanomedicine
/ methods
Xenograft Model Antitumor Assays
src-Family Kinases
/ antagonists & inhibitors
cancer
cyanine
glioblastoma
imaging agents
tumor targeting
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
04 09 2019
04 09 2019
Historique:
received:
11
06
2019
revised:
17
07
2019
pubmed:
20
7
2019
medline:
25
8
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
We hypothesized that conjugation of the near-infrared dye MHI-148 with the anti-leukemia drug dasatinib might produce a potential theranostic for glioblastoma. In fact, the conjugate was found to bind the kinases Src and Lyn, and to inhibit the viability of a glioblastoma cell line with significantly greater potency than dasatinib alone, MHI-148 alone, or a mixture of dasatinib and MHI-148 at the same concentration. It was also used to successfully image a subcutaneous glioblastoma tumor in vivo.
Identifiants
pubmed: 31322832
doi: 10.1002/cmdc.201900356
doi:
Substances chimiques
Antineoplastic Agents
0
Carbocyanines
0
Fluorescent Dyes
0
Indoles
0
MHI-148
0
Protein Kinase Inhibitors
0
lyn protein-tyrosine kinase
EC 2.7.10.2
src-Family Kinases
EC 2.7.10.2
Dasatinib
RBZ1571X5H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1575-1579Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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