Noninvasive characterization of in situ forming implant diffusivity using diffusion-weighted MRI.

Animals Contrast Media / administration & dosage Diffusion Diffusion Magnetic Resonance Imaging Drug Delivery Systems Drug Implants / chemistry Drug Liberation Drug Monitoring Fluorescein / administration & dosage Fluorescent Dyes / administration & dosage Male Mice, Inbred C57BL Polylactic Acid-Polyglycolic Acid Copolymer / chemistry
Controlled release Diffusion-weighted imaging Diffusivity Drug delivery MRI in situ forming implants

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 09 2019
Historique:
received: 15 04 2019
revised: 10 07 2019
accepted: 15 07 2019
pubmed: 20 7 2019
medline: 6 10 2020
entrez: 20 7 2019
Statut: ppublish

Résumé

In situ forming implants (ISFIs) form a solid drug-eluting depot, releasing drug for an extended period of time after a minimally-invasive injection. Clinical use of ISFIs has been limited because many factors affect drug release kinetics. The aim of this study was to use diffusion-weighted MRI (DWI) to noninvasively quantify spatial-temporal changes in implant diffusivity in situ. ISFIs were formed using poly(lactic-co-glycolic) acid, with a molecular weight of either 15 kDa or 52 kDa, and fluorescein as the mock drug. Drug release, polymer erosion, polymer degradation, and implant diffusivity were analyzed in vitro over 21 days. DWI was also performed in vivo over 5 days. Spatial diffusivity maps of the implant were generated using DWI data. Results showed constant diffusivity at the implant shell ((1.17 ± 0.13) × 10

Identifiants

DOI: 10.1016/j.jconrel.2019.07.019 PMID: 31323243 PMC: PMC6815723
pubmed: 31323243
pii: S0168-3659(19)30406-7
doi: 10.1016/j.jconrel.2019.07.019
pmc: PMC6815723
mid: NIHMS1537696
pii:
doi:

Substances chimiques

Contrast Media 0
Drug Implants 0
Fluorescent Dyes 0
Polylactic Acid-Polyglycolic Acid Copolymer 1SIA8062RS
Fluorescein TPY09G7XIR

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

289-301

Subventions

Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA198929
Pays : United States
Organisme : NIBIB NIH HHS
ID : R03 EB026231
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA048074
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

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Auteurs

Kelsey A Hopkins (KA)

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Dr., West Lafayette, IN 47907, USA.

Nicole Vike (N)

Basic Medical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, IN 47907, USA.

Xin Li (X)

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Dr., West Lafayette, IN 47907, USA.

Jacqueline Kennedy (J)

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Dr., West Lafayette, IN 47907, USA.

Emma Simmons (E)

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Dr., West Lafayette, IN 47907, USA.

Joseph Rispoli (J)

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Dr., West Lafayette, IN 47907, USA; Electrical and Computer Engineering, Purdue University, 465 Northwestern Ave., West Lafayette, IN 47907, USA; Center for Cancer Research, Purdue University, 201 S. University St., West Lafayette, IN 47907, USA. Electronic address: jrispoli@purdue.edu.

Luis Solorio (L)

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Dr., West Lafayette, IN 47907, USA; Center for Cancer Research, Purdue University, 201 S. University St., West Lafayette, IN 47907, USA. Electronic address: lsolorio@purdue.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Noninvasive characterization of in situ...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › Noninvasive characterization of in situ...
questionsmedicales.fr › Phénomènes chimiques › Diffusion › Noninvasive characterization of in situ...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique de diffusion › Noninvasive characterization of in situ...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Noninvasive characterization of in situ...
questionsmedicales.fr › Préparations pharmaceutiques › Implant pharmaceutique › Noninvasive characterization of in situ...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Noninvasive characterization of in situ...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Surveillance des médicaments › Noninvasive characterization of in situ...
questionsmedicales.fr › Composés polycycliques › Spiranes › Fluorescéines › Fluorescéine › Noninvasive characterization of in situ...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Noninvasive characterization of in situ...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Noninvasive characterization of in situ...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Acide polyglycolique › Copolymère d'acide poly(lactique-co-glycolique) › Noninvasive characterization of in situ...