Protective Effects of Curcumin Ester Prodrug, Curcumin Diethyl Disuccinate against H
Blotting, Western
Cell Line
Cell Survival
/ drug effects
Curcumin
/ analogs & derivatives
Humans
Hydrogen Peroxide
/ pharmacology
Macular Degeneration
/ metabolism
Oxidative Stress
/ drug effects
Prodrugs
/ pharmacology
Reactive Oxygen Species
/ metabolism
Retinal Pigment Epithelium
/ cytology
Succinates
/ pharmacology
age related macular degeneration
curcumin
curcumin diethyl disuccinate
oxidative stress
retinal pigment epithelium
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jul 2019
09 Jul 2019
Historique:
received:
12
06
2019
revised:
03
07
2019
accepted:
05
07
2019
entrez:
21
7
2019
pubmed:
22
7
2019
medline:
14
1
2020
Statut:
epublish
Résumé
Oxidative stress-induced damage to the retinal pigmented epithelium (RPE), a specialised post-mitotic monolayer that maintains retinal homeostasis, contributes to the development of age-related macular degeneration (AMD). Curcumin (Cur), a naturally occurring antioxidant, was previously shown to have the ability to protect RPE cells from oxidative stress. However, poor solubility and bioavailability makes Cur a poor therapeutic agent. As prodrug approaches can mitigate these limitations, we compared the protective properties of the Cur prodrug curcumin diethyl disuccinate (CurDD) against Cur in relation to oxidative stress induced in human ARPE-19 cells. Both CurDD and Cur significantly decreased H
Identifiants
pubmed: 31323999
pii: ijms20133367
doi: 10.3390/ijms20133367
pmc: PMC6651864
pii:
doi:
Substances chimiques
Prodrugs
0
Reactive Oxygen Species
0
Succinates
0
curcumin diethyl disuccinate
0
Hydrogen Peroxide
BBX060AN9V
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Chulalongkorn University
ID : GCUGR1125602002D
Organisme : Graduate School and the Faculty of Pharmaceutical Sciences, Chulalongkorn University
ID : 2018
Organisme : The Humane Research Trust UK
ID : 2017
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