Role of the Streptomyces spore wall synthesizing complex SSSC in differentiation of Streptomyces coelicolor A3(2).

Bacterial Proteins / genetics Biopolymers / chemistry Cell Wall / chemistry Gene Expression Regulation, Bacterial Models, Biological Multienzyme Complexes Peptidoglycan / chemistry Phosphorylation Spores, Bacterial / genetics Streptomyces coelicolor / classification
Cell envelope Cell wall glycopolymers Phosphorylation Sporulation eSTPK

Journal

International journal of medical microbiology : IJMM
ISSN: 1618-0607
Titre abrégé: Int J Med Microbiol
Pays: Germany
ID NLM: 100898849

Informations de publication

Date de publication:
Sep 2019
Historique:
received: 28 12 2018
revised: 02 07 2019
accepted: 07 07 2019
pubmed: 22 7 2019
medline: 18 12 2019
entrez: 21 7 2019
Statut: ppublish

Résumé

A crucial stage of the Streptomyces life cycle is the sporulation septation, a process were dozens of cross walls are synchronously formed in the aerial hyphae in a highly coordinated manner. This process includes the remodeling of the spore envelopes to make Streptomyces spores resistant to detrimental environmental conditions. Sporulation septation and the synthesis of the thickened spore envelope in S. coelicolor A3(2) involves the Streptomyces spore wall synthesizing complex SSSC. The SSSC is a multi-protein complex including proteins directing peptidoglycan synthesis (MreBCD, PBP2, Sfr, RodZ) and cell wall glycopolymer synthesis (PdtA). It also includes two eukaryotic like serin/threonine protein kinases (eSTPK), PkaI and PkaH, which were shown to phosphorylate MreC. Since unbalancing phosphorylation activity by either deleting eSTPK genes or by expressing a second copy of an eSTPK gene affected proper sporulation, a model was developed, in which the activity of the SSSC is controlled by protein phosphorylation.

Identifiants

DOI: 10.1016/j.ijmm.2019.07.001 PMID: 31324525
pubmed: 31324525
pii: S1438-4221(18)30649-0
doi: 10.1016/j.ijmm.2019.07.001
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Biopolymers 0
Multienzyme Complexes 0
Peptidoglycan 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

151327

Informations de copyright

Copyright © 2019 Elsevier GmbH. All rights reserved.

Auteurs

B Vollmer (B)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

N Steblau (N)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

N Ladwig (N)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

C Mayer (C)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

B Macek (B)

Proteome Center Tuebingen, Interfakultaeres Institut für Zellbiologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany.

L Mitousis (L)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

S Sigle (S)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

A Walter (A)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

W Wohlleben (W)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.

G Muth (G)

Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin Tuebingen IMIT, Mikrobiologie/Biotechnologie, Eberhard Karls Universitaet Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany. Electronic address: gmuth@biotech.uni-tuebingen.de.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Role of the Streptomyces spore wall...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Role of the Streptomyces spore wall...
questionsmedicales.fr › Cellules › Structures cellulaires › Paroi cellulaire › Role of the Streptomyces spore wall...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Role of the Streptomyces spore wall...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Role of the Streptomyces spore wall...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Role of the Streptomyces spore wall...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes bactériens › Polyosides bactériens › Peptidoglycane › Role of the Streptomyces spore wall...
questionsmedicales.fr › Métabolisme › Phosphorylation › Role of the Streptomyces spore wall...
questionsmedicales.fr › Stades d'organismes › Spores › Spores bactériens › Role of the Streptomyces spore wall...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Streptomyces coelicolor › Role of the Streptomyces spore wall...