Characterization of acute TLR-7 agonist-induced hemorrhagic myocarditis in mice by multiparametric quantitative cardiac magnetic resonance imaging.
CMR
Cardiac hemorrhage
Cardiac magnetic resonance imaging
MRI
Myocarditis
Resiquimod
TLR-7
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
16 08 2019
16 08 2019
Historique:
received:
27
05
2019
accepted:
12
07
2019
pubmed:
22
7
2019
medline:
9
4
2020
entrez:
21
7
2019
Statut:
epublish
Résumé
Hemorrhagic myocarditis is a potentially fatal complication of excessive levels of systemic inflammation. It has been reported in viral infection, but is also possible in systemic autoimmunity. Epicutaneous treatment of mice with the Toll-like receptor 7 (TLR-7) agonist Resiquimod induces auto-antibodies and systemic tissue damage, including in the heart, and is used as an inducible mouse model of systemic lupus erythematosus (SLE). Here, we show that overactivation of the TLR-7 pathway of viral recognition by Resiquimod treatment of CFN mice induces severe thrombocytopenia and internal bleeding, which manifests most prominently as hemorrhagic myocarditis. We optimized a cardiac magnetic resonance (CMR) tissue mapping approach for the
Identifiants
pubmed: 31324689
pii: dmm.040725
doi: 10.1242/dmm.040725
pmc: PMC6737951
pii:
doi:
Substances chimiques
Imidazoles
0
Toll-Like Receptor 7
0
Iron
E1UOL152H7
resiquimod
V3DMU7PVXF
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : British Heart Foundation
ID : RG/18/3/33405
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/16/93/32345
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/16/93/32345
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/18/2/33446
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/14/90/31219
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/22/32868
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/14/88/31183
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RM/13/1/30157
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/42/33039
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/17/21/32712
Pays : United Kingdom
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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