Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5.
Plasmodium falciparum
Rosetta
deep sequencing
high-affinity design
host-pathogen interactions
Journal
Proteins
ISSN: 1097-0134
Titre abrégé: Proteins
Pays: United States
ID NLM: 8700181
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
28
02
2019
revised:
02
07
2019
accepted:
12
07
2019
pubmed:
22
7
2019
medline:
25
9
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
Many human pathogens use host cell-surface receptors to attach and invade cells. Often, the host-pathogen interaction affinity is low, presenting opportunities to block invasion using a soluble, high-affinity mimic of the host protein. The Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) provides an exciting candidate for mimicry: it is highly conserved and its moderate affinity binding to the human receptor basigin (K
Identifiants
pubmed: 31325330
doi: 10.1002/prot.25786
pmc: PMC6904230
mid: EMS83783
doi:
Substances chimiques
Carrier Proteins
0
Protozoan Proteins
0
RH5 protein, Plasmodium falciparum
0
Basigin
136894-56-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-195Subventions
Organisme : European Research Council
ID : 815379
Pays : International
Organisme : Wellcome Trust
ID : 100993/Z/13/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106917/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107366/Z/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K501281/1
Pays : United Kingdom
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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