Epigenetic mechanisms of drug resistance in fungi.
Antifungal drug
Candida albicans
Epimutation
Histone modification
Long non-coding RNA
Mucor
Journal
Fungal genetics and biology : FG & B
ISSN: 1096-0937
Titre abrégé: Fungal Genet Biol
Pays: United States
ID NLM: 9607601
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
07
05
2019
revised:
12
07
2019
accepted:
15
07
2019
pubmed:
22
7
2019
medline:
22
5
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
The emergence of drug-resistant fungi poses a continuously increasing threat to human health. Despite advances in preventive care and diagnostics, resistant fungi continue to cause significant mortality, especially in immunocompromised patients. Therapeutic resources are further limited by current usage of only four major classes of antifungal drugs. Resistance against these drugs has already been observed in pathogenic fungi requiring the development of much needed newer antifungal drugs. Epigenetic changes such as DNA or chromatin modifications alter gene expression levels in response to certain stimuli, including interaction with the host in the case of fungal pathogens. These changes can confer resistance to drugs by altering the expression of target genes or genes encoding drug efflux pumps. Multiple pathogens share many of these epigenetic pathways; thus, targeting epigenetic pathways might also identify drug target candidates for the development of broad-spectrum antifungal drugs. In this review, we discuss the importance of epigenetic pathways in mediating drug resistance in fungi as well as in the development of anti-fungal drugs.
Identifiants
pubmed: 31325489
pii: S1087-1845(19)30163-X
doi: 10.1016/j.fgb.2019.103253
pmc: PMC6858951
mid: NIHMS1534953
pii:
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103253Subventions
Organisme : NIAID NIH HHS
ID : R37 AI039115
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI112595
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI039115
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI104533
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007171
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112595
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050113
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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