Oculomotor effects of medical and surgical treatments of Parkinson's disease.
Basal ganglia
Deep brain stimulation
Eye movements
LATER model
Oculomotor
Parkinson's disease
Saccades
Stereotactic neurosurgery
Journal
Progress in brain research
ISSN: 1875-7855
Titre abrégé: Prog Brain Res
Pays: Netherlands
ID NLM: 0376441
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
22
7
2019
pubmed:
22
7
2019
medline:
8
5
2020
Statut:
ppublish
Résumé
Oculomotor abnormalities are fast becoming a proxy for disease diagnosis and progression. Saccades-ballistic eye movements-are known to be affected by dopaminergic cell loss in the basal ganglia, caused by Parkinson's disease. Pharmaceutical and neurosurgical interventions such as deep brain stimulation and functional neurosurgery have both been noted to have an effect on saccades. Comparing and contrasting these effects may yield insights into Parkinson's disease pathophysiology, and the mechanisms of pharmacological and neurosurgical treatments. Computational models of saccadic control, such as the LATER model, can help to interpret the distribution of saccadic latencies, providing a framework for objectively comparing the effects of pharmaceutical interventions and deep brain stimulation.
Identifiants
pubmed: 31325988
pii: S0079-6123(19)30096-2
doi: 10.1016/bs.pbr.2019.04.020
pii:
doi:
Substances chimiques
Antiparkinson Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-305Informations de copyright
© 2019 Elsevier B.V. All rights reserved.