Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.
Adenocarcinoma
/ diagnostic imaging
Animals
Biological Products
/ chemical synthesis
Cell Line
Colon
/ diagnostic imaging
Colorectal Neoplasms
/ diagnostic imaging
Dogs
Fluorescent Dyes
/ chemical synthesis
HL-60 Cells
HeLa Cells
Humans
Kinetics
Microscopy, Fluorescence
Molecular Structure
NAD(P)H Dehydrogenase (Quinone)
/ analysis
Optical Imaging
Quinones
/ chemical synthesis
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
received:
20
05
2019
revised:
08
07
2019
accepted:
10
07
2019
pubmed:
23
7
2019
medline:
23
9
2020
entrez:
23
7
2019
Statut:
ppublish
Résumé
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
Identifiants
pubmed: 31327676
pii: S0968-0896(19)30827-2
doi: 10.1016/j.bmc.2019.07.017
pii:
doi:
Substances chimiques
Biological Products
0
Fluorescent Dyes
0
Quinones
0
NAD(P)H Dehydrogenase (Quinone)
EC 1.6.5.2
NQO1 protein, human
EC 1.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3938-3946Subventions
Organisme : Medical Research Council
ID : EP/L016559/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098493/Z/12/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M025160/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.