The Mitochondrion as an Emerging Therapeutic Target in Cancer.
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
25
04
2019
revised:
10
06
2019
accepted:
14
06
2019
pubmed:
23
7
2019
medline:
8
7
2021
entrez:
23
7
2019
Statut:
ppublish
Résumé
Mitochondria have emerged as important pharmacological targets because of their key role in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic phenotypes to meet the challenges of high energy demand and macromolecular synthesis. Furthermore, mitochondria can engage in crosstalk with the tumor microenvironment, and signals from cancer-associated fibroblasts can impinge on mitochondria. Cancer cells can also acquire a hybrid phenotype in which both glycolysis and oxidative phosphorylation (OXPHOS) can be utilized. This hybrid phenotype can facilitate metabolic plasticity of cancer cells more specifically in metastasis and therapy-resistance. In light of the metabolic heterogeneity and plasticity of cancer cells that had until recently remained unappreciated, strategies targeting cancer metabolic dependency appear to be promising in the development of novel and effective cancer therapeutics.
Identifiants
pubmed: 31327706
pii: S1471-4914(19)30171-6
doi: 10.1016/j.molmed.2019.06.009
pmc: PMC6938552
mid: NIHMS1533221
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-134Subventions
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218545
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209978
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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