Going for the Golgi: small PDI protein helps ATF6 perform better under stress.

Activating Transcription Factor 6 Endoplasmic Reticulum Golgi Apparatus Transcription Factors Unfolded Protein Response

Journal

The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664

Informations de publication

Date de publication:
01 08 2019
Historique:
pubmed: 23 7 2019
medline: 18 12 2019
entrez: 23 7 2019
Statut: ppublish

Résumé

ATF6 is a major signal transducer for cellular reprogramming in response to protein mis-folding in the endoplasmic reticulum. However, the mechanism by which ATF6 senses unfolded proteins and becomes activated is not yet known. In this issue of The EMBO Journal, Oka et al show that ERp18, a single-domain member of the protein disulfide isomerase family, interacts preferentially with ATF6 under stress conditions and regulates ATF6 transport to the Golgi apparatus. Furthermore, ERp18 impacts the ATF6 cleavage product generated in the Golgi, ultimately determining whether or not ATF6 becomes a functional transcription factor and induces the unfolded protein response.

Identifiants

DOI: 10.15252/embj.2019102743 PMID: 31328793 PMC: PMC6669921
pubmed: 31328793
doi: 10.15252/embj.2019102743
pmc: PMC6669921
doi:

Substances chimiques

Activating Transcription Factor 6 0
Transcription Factors 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

e102743

Commentaires et corrections

Type : CommentOn

Informations de copyright

© 2019 The Author.

Références

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pubmed: 12761212
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pubmed: 12110171
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Auteurs

Deborah Fass (D)

Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription ATF › Facteur de transcription ATF-6 › Going for the Golgi: small PDI protein helps...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Going for the Golgi: small PDI protein helps...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Appareil de Golgi › Going for the Golgi: small PDI protein helps...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Going for the Golgi: small PDI protein helps...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Réponse aux protéines mal repliées › Going for the Golgi: small PDI protein helps...