A validated prognostic classifier for

Adult Aged Aged, 80 and over Biomarkers, Tumor / genetics Colorectal Neoplasms / genetics DNA Mutational Analysis Female Genetic Predisposition to Disease Humans Italy Male Middle Aged Mutation Neoplasm Metastasis Phenotype Predictive Value of Tests Prognosis Proto-Oncogene Proteins B-raf / genetics Retrospective Studies Risk Assessment Risk Factors Young Adult
(V600E)BRAF Colorectal cancer Metastases Prognostic markers Scoring system

Journal

European journal of cancer (Oxford, England : 1990)
ISSN: 1879-0852
Titre abrégé: Eur J Cancer
Pays: England
ID NLM: 9005373

Informations de publication

Date de publication:
09 2019
Historique:
received: 25 02 2019
revised: 20 06 2019
accepted: 22 06 2019
pubmed: 23 7 2019
medline: 9 6 2020
entrez: 23 7 2019
Statut: ppublish

Résumé

Despite the well-known negative prognostic value of the Two large retrospective series of A total of 395 These scoring systems are based on easy-to-collect data and defined specific subgroups with relevant differences in their life expectancy. These tools could be useful in clinical practice, would allow better stratification of patients in clinical trials and may be adopted for proper adjustments in exploratory translational analyses.

Sections du résumé

BACKGROUND
Despite the well-known negative prognostic value of the
METHODS
Two large retrospective series of
RESULTS
A total of 395
CONCLUSIONS
These scoring systems are based on easy-to-collect data and defined specific subgroups with relevant differences in their life expectancy. These tools could be useful in clinical practice, would allow better stratification of patients in clinical trials and may be adopted for proper adjustments in exploratory translational analyses.

Identifiants

DOI: 10.1016/j.ejca.2019.06.008 PMID: 31330487
pubmed: 31330487
pii: S0959-8049(19)30376-4
doi: 10.1016/j.ejca.2019.06.008
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
BRAF protein, human EC 2.7.11.1
Proto-Oncogene Proteins B-raf EC 2.7.11.1

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't Validation Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

121-130

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Fotios Loupakis (F)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. Electronic address: fotios.loupakis@iov.veneto.it.

Rossana Intini (R)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Chiara Cremolini (C)

Unit of Medical Oncology 2, Department of Translational Research and New Technologies in Medicine and Surgery, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.

Armando Orlandi (A)

Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy.

Andrea Sartore-Bianchi (A)

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Oncology and Hemato-oncology, Università Degli Studi di Milano, Milan, Italy.

Filippo Pietrantonio (F)

Department of Oncology and Hemato-oncology, Università Degli Studi di Milano, Milan, Italy; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.

Nicoletta Pella (N)

Department of Oncology, University and General Hospital, Udine, Italy.

Andrea Spallanzani (A)

Department of Diagnostic Medicine and Public Health, Section of Pathology, Università di Modena e Reggio Emilia, Policlinico di Modena, Modena, Italy.

Emanuela Dell'Aquila (E)

Medical Oncology, Campus Biomedico University, Rome, Italy.

Mario Scartozzi (M)

Medical Oncology, University of Cagliari, University Hospital, Cagliari, Italy.

Emmanuele De Luca (E)

S.C.D.U. Medical Oncology, A.O. Ordine Mauriziano Hospital, Department of Oncology, University of Turin, Turin, Italy.

Lorenza Rimassa (L)

Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center-IRCCS, Rozzano (MI), Italy.

Vincenzo Formica (V)

Medical Oncology Unit, Tor Vergata University, Rome, Italy.

Francesco Leone (F)

Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Turin, Italy; Department of Oncology, University of Torino, Candiolo, Turin, Italy.

Lorenzo Calvetti (L)

Department of Oncology, San Bortolo General Hospital, ULSS8 Berica - East District, Vicenza, Italy.

Giuseppe Aprile (G)

Department of Oncology, San Bortolo General Hospital, ULSS8 Berica - East District, Vicenza, Italy.

Lorenzo Antonuzzo (L)

Medical Oncology, Careggi University Hospital, Firenze, Italy.

Federica Urbano (F)

Medical Oncology, Policlinico Umberto I, Sapienza, Università Degli Studi di Roma, Rome, Italy.

Hans Prenen (H)

Department of Digestive Oncology, University Hospitals Leuven, Leuven, Belgium.

Francesca Negri (F)

Medical Oncology Unit, University Hospital of Parma, Parma, Italy.

Samantha Di Donato (S)

Department of Medical Oncology, General Hospital, Prato, Italy.

Pasquale Buonandi (P)

Medical Oncology, Sesto San Giovanni Hospital, Sesto San Giovanni (MI), Italy.

Gianluca Tomasello (G)

Medical Oncology Unit, ASST of Cremona, Cremona Hospital, Cremona, Italy.

Antonio Avallone (A)

Experimental Abdomen Medical Oncology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy.

Fable Zustovich (F)

Medical Oncology Unit, Azienda ULSS 1, Belluno, Italy.

Roberto Moretto (R)

Unit of Medical Oncology 2, Department of Translational Research and New Technologies in Medicine and Surgery, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.

Carlotta Antoniotti (C)

Unit of Medical Oncology 2, Department of Translational Research and New Technologies in Medicine and Surgery, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.

Lisa Salvatore (L)

Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy; Unit of Oncology, Polyclinic GB Rossi, AOUI Verona, Italy.

Maria Alessandra Calegari (MA)

Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy.

Salvatore Siena (S)

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Oncology and Hemato-oncology, Università Degli Studi di Milano, Milan, Italy.

Federica Morano (F)

Department of Oncology and Hemato-oncology, Università Degli Studi di Milano, Milan, Italy; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.

Elena Ongaro (E)

Department of Oncology, University and General Hospital, Udine, Italy.

Stefano Cascinu (S)

Department of Diagnostic Medicine and Public Health, Section of Pathology, Università di Modena e Reggio Emilia, Policlinico di Modena, Modena, Italy.

Daniele Santini (D)

Medical Oncology, Campus Biomedico University, Rome, Italy.

Pina Ziranu (P)

Medical Oncology, University of Cagliari, University Hospital, Cagliari, Italy.

Marta Schirripa (M)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Federica Buggin (F)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Alessandra Anna Prete (AA)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Ilaria Depetris (I)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Paola Biason (P)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Sara Lonardi (S)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Vittorina Zagonel (V)

Unit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Matteo Fassan (M)

Unit of Surgical Pathology, Department of Medicine, University of Padua, Padua, Italy.

Massimo Di Maio (M)

S.C.D.U. Medical Oncology, A.O. Ordine Mauriziano Hospital, Department of Oncology, University of Turin, Turin, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A validated prognostic classifier for
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A validated prognostic classifier for
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › A validated prognostic classifier for
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › A validated prognostic classifier for
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › A validated prognostic classifier for
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Analyse de mutations d'ADN › A validated prognostic classifier for
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › A validated prognostic classifier for
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A validated prognostic classifier for
questionsmedicales.fr › Régions géographiques › Europe › Italie › A validated prognostic classifier for
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questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › A validated prognostic classifier for
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questionsmedicales.fr › Phénomènes génétiques › Phénotype › A validated prognostic classifier for
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › A validated prognostic classifier for
questionsmedicales.fr › Diagnostic › Pronostic › A validated prognostic classifier for
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › A validated prognostic classifier for
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