Vitamin D and Phenylbutyrate Supplementation Does Not Modulate Gut Derived Immune Activation in HIV-1.
HIV-1
LL-37
TMAO
clinical trial
kynurenine/tryptophan ratio
microbiota
phenylbutyrate
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Jul 2019
21 Jul 2019
Historique:
received:
20
06
2019
revised:
16
07
2019
accepted:
17
07
2019
entrez:
24
7
2019
pubmed:
25
7
2019
medline:
14
1
2020
Statut:
epublish
Résumé
Dysbiosis and a dysregulated gut immune barrier function contributes to chronic immune activation in HIV-1 infection. We investigated if nutritional supplementation with vitamin D and phenylbutyrate could improve gut-derived inflammation, selected microbial metabolites, and composition of the gut microbiota. Treatment-naïve HIV-1-infected individuals (
Identifiants
pubmed: 31330899
pii: nu11071675
doi: 10.3390/nu11071675
pmc: PMC6682943
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Phenylbutyrates
0
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Banques de données
ClinicalTrials.gov
['NCT01702974']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Vetenskapsrådet
ID : 2014-3238
Organisme : Swedish heart and lung foundation
ID : 2016-0470 and 2016-0815
Organisme : Swedish International Development Agency
ID : 2010-7938
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