Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?
Chromatin
DNA double-strand break repair
G-quadruplex
R-loop
RNA:DNA hybrid
Transcription
Journal
DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
25
7
2019
medline:
25
3
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
Although long overlooked, it is now well understood that DNA does not systematically assemble into a canonical double helix, known as B-DNA, throughout the entire genome but can also accommodate other structures including DNA hairpins, G-quadruplexes and RNA:DNA hybrids. Notably, these non-canonical DNA structures form preferentially at transcriptionally active loci. Acting as replication roadblocks and being targeted by multiple machineries, these structures weaken the genome and render it prone to damage, including DNA double-strand breaks (DSB). In addition, secondary structures also further accumulate upon DSB formation. Here we discuss the potential functions of pre-existing or de novo formed nucleic acid structures, as bona fide repair intermediates or repair roadblocks, especially during Transcription-Coupled DNA Double-Strand Break repair (TC-DSBR), and provide an update on the specialized protein complexes displaying the ability to remove these structures to safeguard genome integrity.
Identifiants
pubmed: 31331819
pii: S1568-7864(19)30214-9
doi: 10.1016/j.dnarep.2019.102661
pmc: PMC6764918
mid: NIHMS1535270
pii:
doi:
Substances chimiques
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102661Subventions
Organisme : NCI NIH HHS
ID : R01 CA198279
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA201268
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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