Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial.
Adult
Biopsy
Diabetes Mellitus, Type 2
/ complications
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Hypoglycemic Agents
/ therapeutic use
Inflammation
/ complications
Liver
/ pathology
Male
Middle Aged
Non-alcoholic Fatty Liver Disease
/ drug therapy
Pioglitazone
/ administration & dosage
Proof of Concept Study
Treatment Outcome
Vitamin E
/ administration & dosage
Vitamins
/ administration & dosage
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
24
01
2019
accepted:
25
04
2019
entrez:
24
7
2019
pubmed:
25
7
2019
medline:
25
4
2020
Statut:
ppublish
Résumé
While vitamin E has shown to improve nonalcoholic steatohepatitis (NASH) in patients without diabetes, information on patients with type 2 diabetes mellitus (T2DM) is lacking. The aim of this study was to determine whether vitamin E, alone or combined with pioglitazone, improves histology in patients with T2DM and NASH. This was a proof-of-concept, randomized, double-blind, placebo-controlled trial conducted from 2010 to 2016. Patients with T2DM and biopsy-proven NASH ( More patients on combination therapy achieved the primary outcome versus placebo (54% vs. 19%, In this proof-of-concept study, combination therapy was better than placebo in improving liver histology in patients with NASH and T2DM. Vitamin E alone did not significantly change the primary histological outcome.
Identifiants
pubmed: 31332029
pii: dc19-0167
doi: 10.2337/dc19-0167
doi:
Substances chimiques
Hypoglycemic Agents
0
Vitamins
0
Vitamin E
1406-18-4
Pioglitazone
X4OV71U42S
Banques de données
ClinicalTrials.gov
['NCT01002547']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1481-1488Informations de copyright
© 2019 by the American Diabetes Association.