A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections.
Animals
Anti-Bacterial Agents
/ pharmacology
Cornea
/ drug effects
Drug Resistance, Multiple, Bacterial
/ drug effects
Drug Therapy, Combination
/ methods
Eye Infections, Bacterial
/ drug therapy
Female
Keratitis
/ drug therapy
Mice
Mice, Inbred C57BL
Microbial Sensitivity Tests
/ methods
Polymyxin B
/ pharmacology
Pseudomonas Infections
/ drug therapy
Pseudomonas aeruginosa
/ drug effects
Rifampin
/ pharmacology
Staphylococcal Infections
/ drug therapy
Staphylococcus aureus
/ drug effects
Trimethoprim
/ pharmacology
antimicrobial combinations
drug discovery
eye
keratitis
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
10
04
2019
accepted:
16
07
2019
pubmed:
25
7
2019
medline:
8
7
2020
entrez:
24
7
2019
Statut:
epublish
Résumé
Bacterial keratitis causes significant blindness, yet antimicrobial resistance has rendered current treatments ineffective. Polymyxin B-trimethoprim (PT) plus rifampin has potent
Identifiants
pubmed: 31332071
pii: AAC.00777-19
doi: 10.1128/AAC.00777-19
pmc: PMC6761539
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Trimethoprim
AN164J8Y0X
Polymyxin B
J2VZ07J96K
Rifampin
VJT6J7R4TR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : K08 EY029012
Pays : United States
Organisme : NIDCR NIH HHS
ID : T90 DE021985
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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