Inter-generational link of obesity in term and preterm births: role of maternal plasma acylcarnitines.
Adolescent
Adult
Biomarkers
/ blood
Body Mass Index
Boston
/ epidemiology
Carnitine
/ analogs & derivatives
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Mothers
/ education
Obesity
/ blood
Pediatric Obesity
/ blood
Pregnancy
Premature Birth
/ blood
Prenatal Exposure Delayed Effects
/ blood
Prospective Studies
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
10
2018
accepted:
10
06
2019
revised:
20
05
2019
pubmed:
25
7
2019
medline:
19
5
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
Acylcarnitines, intermediates of fatty acid oxidation, are known to be involved in obesity and insulin resistance. Since maternal prepregnancy overweight or obesity (OWO) is a recognized major risk factor for offspring OWO, we hypothesized that maternal plasma acylcarnitines may play a role in inter-generational OWO. This study included 1402 mother-child pairs (1043 term, 359 preterm) recruited at birth from 1998-2013 and followed prospectively up to age 18 years at the Boston Medical Center. The primary outcomes were child OWO defined as BMI ≥ 85th percentile for age and sex. The primary exposures were maternal prepregnancy OWO defined as BMI ≥ 25 kg/m Approximately 40% of the children in this study were OWO by age 5. Maternal OWO had a significant association with childhood OWO, both in term and preterm births. β-hydroxybutyryl-carnitine (C4-OH) levels were significantly and positively associated with child OWO among term births after adjustment for potential confounders and multiple-comparisons. Children born to OWO mothers in the top tertile C4-OH levels were at the highest risk of OWO: OR = 3.78 (95%CI: 2.47, 5.79) as compared with those born to non-OWO mothers in the lowest tertile (P for interaction of maternal OWO and C4-OH = 0.035). In a four-way decomposition of mediation/interaction analysis, we estimated that C4-OH levels explained about 27% (se = 0.08) of inter-generational OWO risk (P = 0.001). In contrast, these associations were not observed in preterm births. In this U.S. urban low-income birth cohort, we provide further evidence of the inter-generational link of OWO and reveal the differential role of C4-OH in explaining the inter-generational obesity between term and preterm births. Further investigations are warranted to better understand and prevent the inter-generational transmission of OWO.
Sections du résumé
BACKGROUND/OBJECTIVES
Acylcarnitines, intermediates of fatty acid oxidation, are known to be involved in obesity and insulin resistance. Since maternal prepregnancy overweight or obesity (OWO) is a recognized major risk factor for offspring OWO, we hypothesized that maternal plasma acylcarnitines may play a role in inter-generational OWO.
SUBJECTS/METHODS
This study included 1402 mother-child pairs (1043 term, 359 preterm) recruited at birth from 1998-2013 and followed prospectively up to age 18 years at the Boston Medical Center. The primary outcomes were child OWO defined as BMI ≥ 85th percentile for age and sex. The primary exposures were maternal prepregnancy OWO defined as BMI ≥ 25 kg/m
RESULTS
Approximately 40% of the children in this study were OWO by age 5. Maternal OWO had a significant association with childhood OWO, both in term and preterm births. β-hydroxybutyryl-carnitine (C4-OH) levels were significantly and positively associated with child OWO among term births after adjustment for potential confounders and multiple-comparisons. Children born to OWO mothers in the top tertile C4-OH levels were at the highest risk of OWO: OR = 3.78 (95%CI: 2.47, 5.79) as compared with those born to non-OWO mothers in the lowest tertile (P for interaction of maternal OWO and C4-OH = 0.035). In a four-way decomposition of mediation/interaction analysis, we estimated that C4-OH levels explained about 27% (se = 0.08) of inter-generational OWO risk (P = 0.001). In contrast, these associations were not observed in preterm births.
CONCLUSIONS
In this U.S. urban low-income birth cohort, we provide further evidence of the inter-generational link of OWO and reveal the differential role of C4-OH in explaining the inter-generational obesity between term and preterm births. Further investigations are warranted to better understand and prevent the inter-generational transmission of OWO.
Identifiants
pubmed: 31332276
doi: 10.1038/s41366-019-0417-x
pii: 10.1038/s41366-019-0417-x
pmc: PMC6900290
mid: NIHMS1531731
doi:
Substances chimiques
Biomarkers
0
acylcarnitine
0
Carnitine
S7UI8SM58A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1967-1977Subventions
Organisme : NICHD NIH HHS
ID : R01 HD041702
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD049059
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086013
Pays : United States
Organisme : NICHD NIH HHS
ID : R24 HD042854
Pays : United States
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