PAPP-A concentrations change in patients with gestational diabetes.
Adolescent
Adult
Biomarkers
/ blood
Case-Control Studies
Chorionic Gonadotropin, beta Subunit, Human
/ blood
Diabetes, Gestational
/ blood
Female
Glucose Tolerance Test
Humans
Maternal Serum Screening Tests
/ statistics & numerical data
Middle Aged
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, First
/ blood
Pregnancy-Associated Plasma Protein-A
/ analysis
Young Adult
NT
PAPP-A
gestational diabetes
glucose intolerance
β-hCG
Journal
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
ISSN: 1364-6893
Titre abrégé: J Obstet Gynaecol
Pays: England
ID NLM: 8309140
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
pubmed:
25
7
2019
medline:
24
11
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
Our aim was to assess the relationship between gestational diabetes and glucose intolerance regarding maternal serum PAPP-A and free β-hCG concentrations in first trimester pregnancies. This study was conducted on 278 women between 18-45 years old with singleton pregnancies. The subjects were divided into four groups, according to their 50 and 100 g OGTT results. Group 1 was the Control Group, Group 2 with positive 50 g OGTT results, but negative 100 g, Group 3 had gestational diabetes after testing with 50 g OGTT (≥180 mg/dl) or with 100 g OGTT. Finally Group 4 was made of women with a one single high glucose level after testing with 100 g OGTT. These groups were analysed in terms of OGTT results. In the GDM group, serum PAPP-A concentrations were significantly lower when compared with the Control Group's (
Identifiants
pubmed: 31335241
doi: 10.1080/01443615.2019.1615041
doi:
Substances chimiques
Biomarkers
0
Chorionic Gonadotropin, beta Subunit, Human
0
Pregnancy-Associated Plasma Protein-A
EC 3.4.24.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM