Sclerosing Epithelioid Fibrosarcoma of the Bone With Rare EWSR1-CREB3L3 Translocation Driving Upregulation of the PI3K/mTOR Signaling Pathway.
EWSR1 translocation
Ewing sarcoma
bone tumors
molecular oncology
sarcoma
sclerosing epithelioid fibrosarcoma
Journal
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
ISSN: 1615-5742
Titre abrégé: Pediatr Dev Pathol
Pays: United States
ID NLM: 9809673
Informations de publication
Date de publication:
Historique:
pubmed:
25
7
2019
medline:
28
4
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
Sclerosing epithelioid fibrosarcoma (SEF) is an uncommon neoplasm that rarely presents in bone. It is characterized by epithelioid cells arranged in nests and single-file cords within a sclerotic stromal background which may mimic neoplastic bone. SEF harbors an
Identifiants
pubmed: 31335288
doi: 10.1177/1093526619864230
doi:
Substances chimiques
Biomarkers, Tumor
0
EWSR1-CREB1 fusion protein, human
0
Oncogene Proteins, Fusion
0
MTOR protein, human
EC 2.7.1.1
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM