Daily Intake of Fermented Milk Containing
Adult
Antimicrobial Cationic Peptides
/ chemistry
Cultured Milk Products
Cytokines
/ genetics
Gene Expression Regulation
/ drug effects
Humans
Immunoglobulin A
/ chemistry
Inflammation
/ prevention & control
Lacticaseibacillus casei
/ classification
Male
Middle Aged
Respiratory System
/ immunology
Running
Saliva
/ chemistry
antimicrobial peptides
cytokines
neutrophil infiltration
probiotics
secretory immunoglobulin A
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
22 Jul 2019
22 Jul 2019
Historique:
received:
30
06
2019
revised:
14
07
2019
accepted:
19
07
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
17
1
2020
Statut:
epublish
Résumé
Although Forty-two male marathon runners ingested a fermented milk containing 40 billion of LcS/day (LcS group, Higher proinflammatory cytokine levels in serum and nasal mucosa, and also lower salivary levels of SIgA and antimicrobial peptides, were found immediately post-marathon in the placebo group compared to other time points and to LcS group. In opposite, higher anti-inflammatory levels and reduced neutrophil infiltration on nasal mucosa were found in the LcS group compared to other time points and to the placebo group. For the first time, it is shown that LcS is able to modulate the systemic and airways immune responses post-marathon.
Sections du résumé
BACKGROUND
BACKGROUND
Although
METHODS
METHODS
Forty-two male marathon runners ingested a fermented milk containing 40 billion of LcS/day (LcS group,
RESULTS
RESULTS
Higher proinflammatory cytokine levels in serum and nasal mucosa, and also lower salivary levels of SIgA and antimicrobial peptides, were found immediately post-marathon in the placebo group compared to other time points and to LcS group. In opposite, higher anti-inflammatory levels and reduced neutrophil infiltration on nasal mucosa were found in the LcS group compared to other time points and to the placebo group.
CONCLUSION
CONCLUSIONS
For the first time, it is shown that LcS is able to modulate the systemic and airways immune responses post-marathon.
Identifiants
pubmed: 31336570
pii: nu11071678
doi: 10.3390/nu11071678
pmc: PMC6682935
pii:
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Cytokines
0
Immunoglobulin A
0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2016/04845-3 and #2012/15165-2
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