Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan.
Conplastic mouse strains
glucose metabolism
healthspan
lifespan
mice
mitochondrial DNA (mtDNA)
mitochondrially encoded complex I
mt-Nd2
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
13 07 2019
13 07 2019
Historique:
received:
12
06
2019
revised:
02
07
2019
accepted:
10
07
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
3
1
2020
Statut:
epublish
Résumé
Mitochondrial complex I-the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery-has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA encoded complex I genes and lifespan in humans have been reported, experimental evidence and the functional consequence of such variants is limited to studies using invertebrate models. Here, we present experimental evidence that a homoplasmic mutation in the mitochondrially encoded complex I gene
Identifiants
pubmed: 31337008
pii: genes10070532
doi: 10.3390/genes10070532
pmc: PMC6678443
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Mitochondrial Proteins
0
NADH dehydrogenase subunit 2, mouse
0
Tryptophan
8DUH1N11BX
NADH Dehydrogenase
EC 1.6.99.3
ND5 protein, mouse
EC 1.6.99.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
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