A Sesquiterpenoid from Farfarae Flos Induces Apoptosis of MDA-MB-231 Human Breast Cancer Cells through Inhibition of JAK-STAT3 Signaling.
Animals
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
Chromatography, High Pressure Liquid
Countercurrent Distribution
Female
Humans
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred BALB C
Mice, Nude
Phosphorylation
/ drug effects
Plant Extracts
/ pharmacology
Plants, Medicinal
Sesquiterpenes
/ pharmacology
Signal Transduction
/ drug effects
Triple Negative Breast Neoplasms
/ metabolism
Tussilago
/ chemistry
Farfarae Flos
MDA-MB-231 cells
STAT3
anticancer
sesquiterpenoid
triple-negative breast cancer (TNBC)
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
13 07 2019
13 07 2019
Historique:
received:
07
06
2019
revised:
10
07
2019
accepted:
11
07
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Triple-negative breast cancers (TNBCs) are hard-to-treat breast tumors with poor prognosis, which need to be treated by chemotherapy. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in proliferation, metastasis, and invasion of cancer cells. Therefore, research on searching for promising compounds with metabolism that suppress phosphorylation or transcription of STAT3 in TNBC cells is important. Farfarae Flos is well known as a traditional medicine for treating inflammation. However, few studies have shown that sesquiterpenoids from Farfarae Flos have an anticancer effect. In this study, efficient separation methods and an MTT assay were conducted to isolate an anticancer compound from Farfarae Flos against TNBC MDA-MB-231 cells. Here, 7β-(3-Ethyl-
Identifiants
pubmed: 31337063
pii: biom9070278
doi: 10.3390/biom9070278
pmc: PMC6681226
pii:
doi:
Substances chimiques
Plant Extracts
0
Sesquiterpenes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer. 2007 May 1;109(9):1721-8
pubmed: 17387718
FASEB J. 1999 Oct;13(13):1699-710
pubmed: 10506573
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10602-7
pubmed: 15249664
Nature. 1995 May 18;375(6528):247-50
pubmed: 7746328
Expert Rev Anticancer Ther. 2003 Aug;3(4):546-62
pubmed: 12934666
Cancers (Basel). 2014 Apr 16;6(2):897-925
pubmed: 24743777
Oncogene. 2000 May 15;19(21):2468-73
pubmed: 10851045
J Biol. 2008;7(2):6
pubmed: 18304379
Eur J Biochem. 1997 Sep 15;248(3):615-33
pubmed: 9342212
JAMA. 2006 Jun 7;295(21):2492-502
pubmed: 16757721
Ann Oncol. 2008 May;19(5):861-70
pubmed: 18174609
Cancer Res. 2011 Jun 1;71(11):3972-9
pubmed: 21610112
Food Chem Toxicol. 2017 Oct;108(Pt A):120-127
pubmed: 28733231
Mol Med Rep. 2019 Apr;19(4):2698-2706
pubmed: 30720080
J Agric Food Chem. 2008 Nov 26;56(22):10493-7
pubmed: 18937486
Mol Cell Biol. 1999 Jul;19(7):5106-12
pubmed: 10373559
Nat Cell Biol. 2001 Apr;3(4):339-45
pubmed: 11283606
Blood. 1994 Sep 1;84(5):1415-20
pubmed: 8068938
Redox Biol. 2018 Sep;18:6-15
pubmed: 29890337
Eur J Cancer. 2008 Dec;44(18):2799-805
pubmed: 19008097
J Chromatogr A. 2017 Mar 17;1489:107-114
pubmed: 28215402
Stem Cells. 2009 Oct;27(10):2383-92
pubmed: 19658181
Biomolecules. 2019 May 03;9(5):
pubmed: 31058868
Oncotarget. 2017 Jan 31;8(5):8226-8238
pubmed: 28030809
J Nat Med. 2018 Sep;72(4):937-945
pubmed: 30043217
Science. 1995 Jul 7;269(5220):81-3
pubmed: 7541555
Breast Cancer Res. 2011 Mar 02;13(2):R22
pubmed: 21366896
Cancer Sci. 2019 Mar;110(3):950-961
pubmed: 30648776
Cell Growth Differ. 1997 Dec;8(12):1267-76
pubmed: 9419415
Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5
pubmed: 15781862
Mol Cancer Res. 2007 Sep;5(9):943-55
pubmed: 17855663
Biol Pharm Bull. 2005 Mar;28(3):455-60
pubmed: 15744068
Fitoterapia. 2012 Mar;83(2):318-22
pubmed: 22120501
N Engl J Med. 2010 Nov 11;363(20):1938-48
pubmed: 21067385
Epidemiol Rev. 1993;15(1):17-35
pubmed: 8405201
Curr Med Chem. 2011;18(26):4012-8
pubmed: 21824090
J Natl Cancer Inst. 1995 Nov 15;87(22):1681-5
pubmed: 7473816
Chem Biol Interact. 2013 Oct 5;205(3):212-21
pubmed: 23867902
Cancer Lett. 2015 Feb 1;357(1):393-403
pubmed: 25434800
Oncol Rep. 2014 Aug;32(2):821-8
pubmed: 24890449
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787
Anticancer Drugs. 2005 Jul;16(6):601-7
pubmed: 15930886
J Ethnopharmacol. 2014 Aug 8;155(1):796-800
pubmed: 24955560
Ann Oncol. 2012 Aug;23 Suppl 6:vi7-12
pubmed: 23012306
Asian Pac J Cancer Prev. 2012;13(6):2873-7
pubmed: 22938476
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16975-80
pubmed: 24082147
J Clin Oncol. 2012 Mar 20;30(9):1005-14
pubmed: 22355058
Ecancermedicalscience. 2017 Jun 08;11:746
pubmed: 28690677
Arch Pharm Res. 2016 Jan;39(1):127-32
pubmed: 26474586
Zhongguo Zhong Yao Za Zhi. 2010 May;35(9):1142-4
pubmed: 20707069