Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor.

Tat peptide amphibian Bowman-Birk inhibitor antifungal drug design molecular cloning protease inhibitor

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
14 07 2019
Historique:
received: 31 05 2019
revised: 11 07 2019
accepted: 12 07 2019
entrez: 25 7 2019
pubmed: 25 7 2019
medline: 9 4 2020
Statut: epublish

Résumé

Anuran amphibian skin secretions are a rich source of peptides, many of which represent novel protease inhibitors and can potentially act as a source for protease inhibitor drug discovery. In this study, a novel bioactive Bowman-Birk type inhibitory hexadecapeptide of the Ranacyclin family from the defensive skin secretion of the Fukien gold-striped pond frog,

Identifiants

pubmed: 31337113
pii: biom9070280
doi: 10.3390/biom9070280
pmc: PMC6681222
pii:
doi:

Substances chimiques

Antifungal Agents 0
Protease Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Yuxi Miao (Y)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.

Guanzhu Chen (G)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.

Xinping Xi (X)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.

Chengbang Ma (C)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK. c.ma@qub.ac.uk.

Lei Wang (L)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.

James F Burrows (JF)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.

Jinao Duan (J)

Jiangsu Key Laboratory for Traditional Chinese Medicine (TCM) Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, China.

Mei Zhou (M)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK. m.zhou@qub.ac.uk.

Tianbao Chen (T)

Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland BT7 1NN, UK.

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Classifications MeSH