A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
18
04
2019
revised:
24
06
2019
accepted:
18
07
2019
pubmed:
25
7
2019
medline:
13
8
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
By examination of the cancer genomics database, we identified a new set of mutations in core histones that frequently recur in cancer patient samples and are predicted to disrupt nucleosome stability. In support of this idea, we characterized a glutamate to lysine mutation of histone H2B at amino acid 76 (H2B-E76K), found particularly in bladder and head and neck cancers, that disrupts the interaction between H2B and H4. Although H2B-E76K forms dimers with H2A, it does not form stable histone octamers with H3 and H4
Identifiants
pubmed: 31337617
pii: 2159-8290.CD-19-0393
doi: 10.1158/2159-8290.CD-19-0393
pmc: PMC6774836
mid: NIHMS1535685
doi:
Substances chimiques
Histones
0
Nucleosomes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1438-1451Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB014869
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM108569
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM115945
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA143869
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA193419
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2019 American Association for Cancer Research.
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