Antidiarrheal, vasorelaxant, and neuropharmacological actions of the diterpene tilifodiolide.
Animals
Anti-Anxiety Agents
/ pharmacology
Antidepressive Agents
/ pharmacology
Antidiarrheals
/ pharmacology
Behavior, Animal
/ drug effects
Diterpenes
/ antagonists & inhibitors
Dose-Response Relationship, Drug
Drug Interactions
Flumazenil
/ pharmacology
Hypnotics and Sedatives
/ pharmacology
Male
Mice
Muscle, Smooth
/ drug effects
NG-Nitroarginine Methyl Ester
/ pharmacology
Oxadiazoles
/ pharmacology
Quinoxalines
/ pharmacology
Vasodilator Agents
/ antagonists & inhibitors
Yohimbine
/ pharmacology
Salvia tiliifolia
antidiarrheal
anxiolytic
tilifodiolide
vasorelaxant
Journal
Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
27
03
2019
revised:
23
06
2019
accepted:
13
07
2019
pubmed:
26
7
2019
medline:
21
4
2020
entrez:
26
7
2019
Statut:
ppublish
Résumé
Salvia tiliifolia is used in folk medicine as a relaxant agent and for the treatment of diarrhea and neurodegenerative diseases. Tilifodiolide (TFD) is a diterpene obtained from this plant. The purpose of this work was to evaluate the antidiarrheal, vasorelaxant, and neuropharmacological actions of TFD. These effects were selected based on the folk medicinal use of S. tiliifolia. The antidiarrheal activity of 1-50 mg/kg p.o. TFD was assessed with the castor oil related tests. The vasorelaxant effect of TFD (0.9-298 μM) was performed with smooth muscle tissues from rats, and its mechanism of action was evaluated using different inhibitors. The sedative, anxiolytic, and antidepressant effects of 1-100 mg/kg TFD were assessed. The possible mechanisms of action of the anxiolytic and antidepressant effects of TFD were evaluated using inhibitors. TFD exhibited antidiarrheal (ED
Substances chimiques
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
0
Anti-Anxiety Agents
0
Antidepressive Agents
0
Antidiarrheals
0
Diterpenes
0
Hypnotics and Sedatives
0
Oxadiazoles
0
Quinoxalines
0
Vasodilator Agents
0
tilifodiolide
0
Yohimbine
2Y49VWD90Q
Flumazenil
40P7XK9392
NG-Nitroarginine Methyl Ester
V55S2QJN2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
981-991Informations de copyright
© 2019 Wiley Periodicals, Inc.
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