Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN.
Adult
Aged
Agriculture
Animals
Carbamates
/ analysis
Carcinogens
/ analysis
Central Nervous System Neoplasms
/ epidemiology
Cohort Studies
Crops, Agricultural
Environmental Monitoring
Female
France
/ epidemiology
Fungicides, Industrial
/ analysis
Glioma
/ epidemiology
Herbicides
/ analysis
Humans
Incidence
Male
Meningioma
/ epidemiology
Middle Aged
Occupational Exposure
/ analysis
CNS tumors
Carbamates
Cohort studies
Dithiocarbamates
Fungicides
Herbicides
Occupational exposure
Risk factors
Thiocarbamates
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
20
12
2018
revised:
27
05
2019
accepted:
27
05
2019
pubmed:
26
7
2019
medline:
5
3
2020
entrez:
26
7
2019
Statut:
ppublish
Résumé
Pesticides exposures could be implicated in the excess of Central Nervous System (CNS) tumors observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate derivative pesticides, including herbicides and fungicides (i.e. (thio/dithio)-carbamates), have shown evidence of carcinogenicity in experimental studies in animals. In the French AGRICAN cohort, we assessed the associations between potential exposures to carbamate herbicides and fungicides and the incidence of CNS tumors, overall and by histological subtype. AGRICAN enrolled 181,842 participants involved in agriculture. Incident CNS tumors were identified by linkage with cancer registries from enrollment (2005-2007) until 2013. Individual exposures were assessed by combining information on lifetime periods of pesticide use on crops and the French crop-exposure matrix PESTIMAT, for each of the 14 carbamate and thiocarbamate herbicides and the 16 carbamate and dithiocarbamate fungicides registered in France since 1950. Associations were estimated using proportional hazard models with age as the underlying timescale, adjusting for gender, educational level and smoking. During an average follow-up of 6.9 years, 381 incident cases of CNS tumors occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumors with overall exposure to carbamate fungicides (Hazard Ratio, HR = 1.88; 95% CI: 1.27-2.79) and, to a lesser extent, to carbamate herbicides (HR = 1.44; 95% CI: 0.94-2.22). Positive associations were observed with specific carbamates, including some fungicides (mancozeb, maneb, metiram) and herbicides (chlorpropham, propham, diallate) already suspected of being carcinogens in humans. Although some associations need to be corroborate in further studies and should be interpreted cautiously, these findings provide additional carcinogenicity evidence for several carbamate fungicides and herbicides.
Sections du résumé
BACKGROUND
Pesticides exposures could be implicated in the excess of Central Nervous System (CNS) tumors observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate derivative pesticides, including herbicides and fungicides (i.e. (thio/dithio)-carbamates), have shown evidence of carcinogenicity in experimental studies in animals. In the French AGRICAN cohort, we assessed the associations between potential exposures to carbamate herbicides and fungicides and the incidence of CNS tumors, overall and by histological subtype.
METHODS
AGRICAN enrolled 181,842 participants involved in agriculture. Incident CNS tumors were identified by linkage with cancer registries from enrollment (2005-2007) until 2013. Individual exposures were assessed by combining information on lifetime periods of pesticide use on crops and the French crop-exposure matrix PESTIMAT, for each of the 14 carbamate and thiocarbamate herbicides and the 16 carbamate and dithiocarbamate fungicides registered in France since 1950. Associations were estimated using proportional hazard models with age as the underlying timescale, adjusting for gender, educational level and smoking.
RESULTS
During an average follow-up of 6.9 years, 381 incident cases of CNS tumors occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumors with overall exposure to carbamate fungicides (Hazard Ratio, HR = 1.88; 95% CI: 1.27-2.79) and, to a lesser extent, to carbamate herbicides (HR = 1.44; 95% CI: 0.94-2.22). Positive associations were observed with specific carbamates, including some fungicides (mancozeb, maneb, metiram) and herbicides (chlorpropham, propham, diallate) already suspected of being carcinogens in humans.
CONCLUSIONS
Although some associations need to be corroborate in further studies and should be interpreted cautiously, these findings provide additional carcinogenicity evidence for several carbamate fungicides and herbicides.
Identifiants
pubmed: 31344646
pii: S0160-4120(18)33169-6
doi: 10.1016/j.envint.2019.05.070
pii:
doi:
Substances chimiques
Carbamates
0
Carcinogens
0
Fungicides, Industrial
0
Herbicides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104876Investigateurs
P Arveux
(P)
S Bara
(S)
A M Bouvier
(AM)
T Busquet
(T)
M Colonna
(M)
G Coureau
(G)
M Delanoé
(M)
P Grosclaude
(P)
A V Guizard
(AV)
P Herbrecht
(P)
J J Laplante
(JJ)
B Lapotre-Ledoux
(B)
G Launoy
(G)
D Lenoir
(D)
E Marrer
(E)
E Marcotullio
(E)
M Maynadié
(M)
F Molinié
(F)
A Monnereau
(A)
A Paumier
(A)
P Pouzet
(P)
J M Thibaudier
(JM)
X Troussard
(X)
M Velten
(M)
E Wavelet
(E)
A S Woronoff
(AS)
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.