Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry.
biomonitoring
glucuronidation
high-resolution mass spectrometry (HRMS)
human
metabolism
microsomal incubation
mycotoxins
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
24 07 2019
24 07 2019
Historique:
received:
15
06
2019
revised:
18
07
2019
accepted:
19
07
2019
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
22
9
2020
Statut:
epublish
Résumé
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to measure metabolites in vivo after exposure and to establish which mycotoxin metabolites should be prioritized for the inclusion during large-scale biomonitoring efforts. The objective of this study was to perform human in vitro microsomal incubations of 17 mycotoxins and systematically characterize all resulting metabolites using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The results obtained were then used to build a comprehensive LC-MS library and expand a validated 17-mycotoxin method for exposure monitoring to screening of additional 188 metabolites, including 100 metabolites reported for the first time. The final method represents one of the most comprehensive LC-HRMS methods for mycotoxin biomonitoring or metabolism/fate studies.
Identifiants
pubmed: 31344861
pii: toxins11080433
doi: 10.3390/toxins11080433
pmc: PMC6723440
pii:
doi:
Substances chimiques
Glucuronides
0
Mycotoxins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Arch Anim Nutr. 2014 Dec;68(6):425-47
pubmed: 25355041
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Mar;25(3):347-55
pubmed: 18311625
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:191-200
pubmed: 29278819
Cancer Res. 1994 Jan 1;54(1):101-8
pubmed: 8261428
J Chromatogr A. 2013 Aug 23;1304:61-8
pubmed: 23871563
Mutagenesis. 2002 Nov;17(6):471-81
pubmed: 12435844
Food Addit Contam. 2003 May;20(5):494-504
pubmed: 12775469
Chem Res Toxicol. 2002 Jun;15(6):780-92
pubmed: 12067245
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6121-5
pubmed: 9177180
Toxins (Basel). 2016 Mar 26;8(4):94
pubmed: 27023609
Arch Toxicol. 1996;71(1-2):64-71
pubmed: 9010587
J Agric Food Chem. 2018 Aug 1;66(30):8160-8168
pubmed: 29996643
Food Nutr Bull. 2005 Mar;26(1):49-56
pubmed: 15810799
J Agric Food Chem. 2008 Jun 11;56(11):4032-8
pubmed: 18476699
Food Chem. 2012 Nov 15;135(2):423-9
pubmed: 22868109
J Chromatogr A. 2018 May 4;1548:51-63
pubmed: 29576275
J Agric Food Chem. 2017 Aug 23;65(33):7217-7227
pubmed: 28737905
Compr Rev Food Sci Food Saf. 2018 Sep;17(5):1127-1155
pubmed: 33350155
J Agric Food Chem. 2017 Dec 27;65(51):11292-11303
pubmed: 29205036
Toxicol Lett. 2012 May 20;211(1):85-90
pubmed: 22429874
Toxicol Lett. 2019 May 15;306:43-52
pubmed: 30769082
Anal Chim Acta. 2012 Sep 5;741:58-69
pubmed: 22840705
Arch Toxicol. 2015 Nov;89(11):1993-2005
pubmed: 25209565
Int J Environ Res Public Health. 2017 Jun 13;14(6):
pubmed: 28608841
J Sep Sci. 2017 Apr;40(7):1572-1582
pubmed: 28217904
Appl Environ Microbiol. 2013 Mar;79(6):1821-5
pubmed: 23315729
Int J Cancer. 2005 Jul 20;115(6):879-84
pubmed: 15723309
Toxicol In Vitro. 2015 Apr;29(3):575-81
pubmed: 25645597
Toxins (Basel). 2017 Oct 19;9(10):
pubmed: 29048356
Toxicol Sci. 2010 Jan;113(1):216-25
pubmed: 19875679
Drug Metab Dispos. 2008 Jun;36(6):1119-25
pubmed: 18362161
Drug Metab Pharmacokinet. 2009;24(3):235-44
pubmed: 19571435
Arch Toxicol. 2018 Sep;92(9):2779-2791
pubmed: 30019167
Anal Bioanal Chem. 2017 May;409(13):3369-3382
pubmed: 28299415
J AOAC Int. 2012 Jul-Aug;95(4):1084-8
pubmed: 22970576
Anal Chem. 2014 Dec 2;86(23):11533-7
pubmed: 25372979
J Agric Food Chem. 2013 Oct 9;61(40):9734-43
pubmed: 23971727
Cancer Res. 1978 Apr;38(4):999-1002
pubmed: 639051
Int J Mol Sci. 2009 Apr 21;10(4):1824-37
pubmed: 19468341
Toxins (Basel). 2014 Jul 08;6(7):1996-2007
pubmed: 25007123
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):864-71
pubmed: 18569005
Toxicol Res (Camb). 2016 Jan 7;5(2):377-387
pubmed: 30090353
Mycotoxin Res. 2012 May;28(2):79-87
pubmed: 23606045
Chem Res Toxicol. 2001 Jul;14(7):919-26
pubmed: 11453740
Mol Nutr Food Res. 2010 Oct;54(10):1468-76
pubmed: 20397195
J Anal Toxicol. 2007 Apr;31(3):150-6
pubmed: 17579962
Sci Rep. 2018 Mar 27;8(1):5255
pubmed: 29588479
Toxins (Basel). 2017 Jun 22;9(7):
pubmed: 28640201
J Toxicol Environ Health A. 2016;79(22-23):1015-1025
pubmed: 27924714
J Agric Food Chem. 2012 Oct 10;60(40):10170-8
pubmed: 22967261
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(7):1175-84
pubmed: 25952817
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Jun;28(6):762-6
pubmed: 21623500
Arch Toxicol. 2014 Sep;88(9):1635-44
pubmed: 25027283
Toxicol Lett. 2010 Feb 15;192(3):379-86
pubmed: 19931366
Toxins (Basel). 2014 Jan 28;6(2):523-38
pubmed: 24476712
Environ Int. 2015 Nov;84:82-9
pubmed: 26233555
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1;958:75-82
pubmed: 24705534
Chem Res Toxicol. 2012 Dec 17;25(12):2715-7
pubmed: 23106612
Anal Bioanal Chem. 2011 Nov;401(9):2831-41
pubmed: 21892639
Rapid Commun Mass Spectrom. 2012 Jul 15;26(13):1533-40
pubmed: 22638970
Food Addit Contam. 2004 Oct;21(10):971-81
pubmed: 15712522
Toxins (Basel). 2016 Jul 28;8(8):
pubmed: 27483321
J Food Prot. 2016 Dec;79(12):2143-2159
pubmed: 28221957
Toxins (Basel). 2017 Jun 29;9(7):
pubmed: 28661468
Food Addit Contam. 2003 Jun;20(6):579-82
pubmed: 12881132
Food Chem Toxicol. 2014 Oct;72:69-75
pubmed: 25042512