Increased Expression of Fibronectin Leucine-Rich Transmembrane Protein 3 in the Dorsal Root Ganglion Induces Neuropathic Pain in Rats.
DRG
FLRT3
hyperalgesia
pain
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
18 09 2019
18 09 2019
Historique:
received:
04
02
2019
revised:
17
05
2019
accepted:
06
06
2019
pubmed:
28
7
2019
medline:
1
7
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Neuropathic pain is a chronic condition that occurs frequently after nerve injury and induces hypersensitivity or allodynia characterized by aberrant neuronal excitability in the spinal cord dorsal horn. Fibronectin leucine-rich transmembrane protein 3 (FLRT3) is a modulator of neurite outgrowth, axon pathfinding, and cell adhesion, which is upregulated in the dorsal horn following peripheral nerve injury. However, the function of FLRT3 in adults remains unknown. Therefore, we aimed to investigate the involvement of spinal FLRT3 in neuropathic pain using rodent models. In the dorsal horns of male rats, FLRT3 protein levels increased at day 4 after peripheral nerve injury. In the DRG, FLRT3 was expressed in activating transcription factor 3-positive, injured sensory neurons. Peripheral nerve injury stimulated
Identifiants
pubmed: 31346030
pii: JNEUROSCI.0295-19.2019
doi: 10.1523/JNEUROSCI.0295-19.2019
pmc: PMC6750942
doi:
Substances chimiques
FLRT3 protein, human
0
FLRT3 protein, rat
0
Membrane Glycoproteins
0
Membrane Proteins
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7615-7627Informations de copyright
Copyright © 2019 the authors.
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