Longitudinal follow-up of biopsy-proven small fiber neuropathy.
Adolescent
Adult
Aged
Aged, 80 and over
Analgesics
/ therapeutic use
Autonomic Nervous System Diseases
/ etiology
Biopsy
Employment
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Mobility Limitation
Neuralgia
/ drug therapy
Prognosis
Retrospective Studies
Small Fiber Neuropathy
/ complications
Young Adult
autonomic dysfunction
gait disorder
intraepidermal nerve fiber density
large fiber neuropathy
neuropathic pain
small fiber neuropathy
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
09
2018
revised:
19
07
2019
accepted:
21
07
2019
pubmed:
28
7
2019
medline:
15
1
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Little is published on the prognosis of small fiber neuropathy (SFN). A retrospective analysis of 101 patients with biopsy proven SFN. Study participants included 87 patients with length-dependent SFN and 14 patients with non-length-dependent SFN. The average duration of symptoms was 3.2 years prior to SFN diagnosis, and the average follow-up duration after diagnosis was 6.2 years. Neuropathic pain was present in 98% of patients and in 84.2% of patients at the final visit. The average total number of pain medications ever used was 4.4 per patient. Signs of autonomic dysfunction were initially present in 24.8% of patients, but improved in most. Large fiber involvement was seen in 11.9% of patients. Small fiber neuropathy affected employment and ambulation status in 5.3% and 6.3% of patients, respectively. Small fiber neuropathy tends to be stable and rarely affects ambulation and employment status. Effective pain control remains a challenge.
Substances chimiques
Analgesics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
376-381Informations de copyright
© 2019 Wiley Periodicals, Inc.
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