Novel insights into breast cancer progression and metastasis: A multidisciplinary opportunity to transition from biology to clinical oncology.

Biomarkers, Tumor / genetics Breast Neoplasms / drug therapy Disease Progression Drug Resistance, Neoplasm / genetics Epithelial-Mesenchymal Transition / genetics Female Humans Medical Oncology / trends Neoplasm Metastasis
Artificial intelligence BCSCs Breast cancer EMT Molecular imaging Personalized medicine Therapy

Journal

Biochimica et biophysica acta. Reviews on cancer
ISSN: 1879-2561
Titre abrégé: Biochim Biophys Acta Rev Cancer
Pays: Netherlands
ID NLM: 9806362

Informations de publication

Date de publication:
08 2019
Historique:
received: 20 05 2019
revised: 25 06 2019
accepted: 15 07 2019
pubmed: 28 7 2019
medline: 20 9 2019
entrez: 27 7 2019
Statut: ppublish

Résumé

According to the most recent epidemiological studies, breast cancer shows the highest incidence and the second leading cause of death in women. Cancer progression and metastasis are the main events related to poor survival of breast cancer patients. This can be explained by the presence of highly resistant to chemo- and radiotherapy stem cells in many breast tumor tissues. In this context, numerous studies highlighted the possible involvement of epithelial to mesenchymal transition phenomenon as biological program to generate cancer stem cells, and thus participate to both metastatic and drug resistance process. Therefore, the comprehension of mechanisms (both cellular and molecular) involved in breast cancer occurrence and progression can lay the foundation for the development of new diagnostic and therapeutical protocols. In this review, we reported the most important findings in the field of breast cancer highlighting the most recent data concerning breast tumor biology, diagnosis and therapy.

Identifiants

DOI: 10.1016/j.bbcan.2019.07.002 PMID: 31348975
pubmed: 31348975
pii: S0304-419X(19)30087-3
doi: 10.1016/j.bbcan.2019.07.002
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

138-148

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Manuel Scimeca (M)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy; San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy; Fondazione Umberto Veronesi (FUV), Piazza Velasca 5, 20122 Milano (Mi), Italy. Electronic address: manuel.scimeca@uniroma2.it.

Nicoletta Urbano (N)

Nuclear Medicine, Policlinico "Tor Vergata", Rome, Italy.

Rita Bonfiglio (R)

Department of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.

Andrea Duggento (A)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.

Nicola Toschi (N)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging and Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.

Orazio Schillaci (O)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy; IRCCS Neuromed, Pozzilli, Italy.

Elena Bonanno (E)

Department of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy; Neuromed Group, "Diagnostica Medica" and "Villa dei Platani", Avellino, Italy.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Novel insights into breast cancer progression...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Novel insights into breast cancer progression...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Novel insights into breast cancer progression...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Novel insights into breast cancer progression...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › Novel insights into breast cancer progression...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel insights into breast cancer progression...
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Oncologie médicale › Novel insights into breast cancer progression...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Novel insights into breast cancer progression...