Mannosylated graphene oxide as macrophage-targeted delivery system for enhanced intracellular M.tuberculosis killing efficiency.

Animals Drug Delivery Systems Graphite / chemistry Humans Macaca mulatta Macrophages / metabolism Mannose / chemistry Mycobacterium tuberculosis / metabolism Nanoparticles / chemistry Rifampin / chemistry THP-1 Cells Tuberculosis / drug therapy
Graphene oxide Macrophage targeting Mannose receptor Mycobacterium tuberculosis Rifampicin delivery

Journal

Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 09 04 2018
revised: 23 04 2019
accepted: 19 05 2019
entrez: 28 7 2019
pubmed: 28 7 2019
medline: 31 12 2019
Statut: ppublish

Résumé

Tuberculosis (TB), caused by M.tuberculosis (Mtb), has become a top killer among infectious diseases. Enhancing the ability of anti-TB drugs to kill intracellular Mtb in host cells remains a big challenge. Here, an innovative nano-system was developed to increase drug delivery and Mtb-killing efficacy in Mtb-infected macrophages. We employed mannose surface decoration to develop mannosylated and PEGylated graphene oxide (GO-PEG-MAN). Such nano-platform exhibited increased uptake by macrophages via mannose receptor-mediated endocytosis in vitro. Interestingly, drug-loaded GO-PEG-MAN was preferentially up-taken by mannose receptor-expressing mucosal CD14

Identifiants

DOI: 10.1016/j.msec.2019.109777 PMID: 31349400
pubmed: 31349400
pii: S0928-4931(18)31032-4
doi: 10.1016/j.msec.2019.109777
pii:
doi:

Substances chimiques

graphene oxide 0
Graphite 7782-42-5
Mannose PHA4727WTP
Rifampin VJT6J7R4TR

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109777

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Jiang Pi (J)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Microbiology, Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong Province 510275, China.

Ling Shen (L)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address: lshen@uic.edu.

Hongbo Shen (H)

Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China. Electronic address: hongboshen109@hotmail.com.

Enzhuo Yang (E)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Microbiology, Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong Province 510275, China.

Wandang Wang (W)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

Richard Wang (R)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

Dan Huang (D)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

Bao-Shiang Lee (BS)

Protein Research Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL 60612, USA.

Chunmiao Hu (C)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

Crystal Chen (C)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

Hua Jin (H)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

Jiye Cai (J)

State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau 999078, China.

Gucheng Zeng (G)

Department of Microbiology, Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong Province 510275, China. Electronic address: zenggch@mail.sysu.edu.cn.

Zheng W Chen (ZW)

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mannosylated graphene oxide as...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Mannosylated graphene oxide as...
questionsmedicales.fr › Produits chimiques inorganiques › Minéraux › Graphite › Mannosylated graphene oxide as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mannosylated graphene oxide as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Mannosylated graphene oxide as...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Mannosylated graphene oxide as...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Mannose › Mannosylated graphene oxide as...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Mannosylated graphene oxide as...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Mannosylated graphene oxide as...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Lactames macrocycliques › Rifamycine › Rifampicine › Mannosylated graphene oxide as...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules THP-1 › Mannosylated graphene oxide as...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Mannosylated graphene oxide as...