Antimicrobial emulsions: Formulation of a triggered release reactive oxygen delivery system.

Anti-Bacterial Agents / chemistry Bacteria / growth & development Delayed-Action Preparations / chemistry Emulsions Oils / chemistry Paraffin / chemistry Reactive Oxygen Species / chemistry
AMR Antimicrobial CPI Emulsion Formulation Honey Inversion ROS Surgihoney SurgihoneyRO

Journal

Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 12 10 2018
revised: 15 03 2019
accepted: 08 05 2019
entrez: 28 7 2019
pubmed: 28 7 2019
medline: 31 12 2019
Statut: ppublish

Résumé

The enzyme glucose oxidase mediates the oxidation of glucose to produce reactive oxygen species (ROS), such as hydrogen peroxide. This reaction and its products are key to providing honey with its antimicrobial properties. Currently, honey is an adherent, highly viscous product that produces ROS by means of a water-initiated reaction. These properties reduce clinical usability and present a formulation problem for long term stability. This study aims to engineer a water-in-oil emulsion containing an engineered honey (SurgihoneyRO™) that is easy to administer topically and is controllably activated in-situ. Paraffin oil continuous emulsions formulated using the emulsifier polyglycerol polyricinoleate displayed shear-thinning characteristics. Viscosities between 1.4 and 19.3 Pa·s were achieved at a shear rate representative of post-mixing conditions (4.1 s

Identifiants

DOI: 10.1016/j.msec.2019.05.020 PMID: 31349428
pubmed: 31349428
pii: S0928-4931(18)33131-X
doi: 10.1016/j.msec.2019.05.020
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Delayed-Action Preparations 0
Emulsions 0
Oils 0
Reactive Oxygen Species 0
Paraffin 8002-74-2
paraffin oils 8012-95-1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109735

Informations de copyright

Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.

Auteurs

Thomas J Hall (TJ)

School of Chemical Engineering, University of Birmingham, Edgbaston, B15 2TT, United Kingdom of Great Britain and Northern Ireland. Electronic address: txh544@bham.ac.uk.

Jessica M A Blair (JMA)

Institute of Microbiology and Infection, University of Birmingham, Edgbaston, B15 2TT, United Kingdom of Great Britain and Northern Ireland. Electronic address: j.m.a.blair@bham.ac.uk.

Richard J A Moakes (RJA)

School of Chemical Engineering, University of Birmingham, Edgbaston, B15 2TT, United Kingdom of Great Britain and Northern Ireland. Electronic address: r.j.a.moakes@bham.ac.uk.

Edward G Pelan (EG)

School of Chemical Engineering, University of Birmingham, Edgbaston, B15 2TT, United Kingdom of Great Britain and Northern Ireland. Electronic address: e.pelan@bham.ac.uk.

Liam M Grover (LM)

School of Chemical Engineering, University of Birmingham, Edgbaston, B15 2TT, United Kingdom of Great Britain and Northern Ireland. Electronic address: l.m.grover@bham.ac.uk.

Sophie C Cox (SC)

School of Chemical Engineering, University of Birmingham, Edgbaston, B15 2TT, United Kingdom of Great Britain and Northern Ireland. Electronic address: s.c.cox@bham.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antimicrobial emulsions: Formulation of a...
questionsmedicales.fr › Bactéries › Antimicrobial emulsions: Formulation of a...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Préparations à action retardée › Antimicrobial emulsions: Formulation of a...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Émulsions › Antimicrobial emulsions: Formulation of a...
questionsmedicales.fr › Lipides › Huiles › Antimicrobial emulsions: Formulation of a...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Paraffine › Antimicrobial emulsions: Formulation of a...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Antimicrobial emulsions: Formulation of a...