Acute primary testicular failure due to radiotherapy increases risk of severe postoperative adverse events in rectal cancer patients.
Leydig cell function
Preoperative radiotherapy
Rectal cancer
Testicular dose
Testosterone
Journal
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
ISSN: 1532-2157
Titre abrégé: Eur J Surg Oncol
Pays: England
ID NLM: 8504356
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
08
05
2019
revised:
15
07
2019
accepted:
18
07
2019
pubmed:
28
7
2019
medline:
23
7
2020
entrez:
28
7
2019
Statut:
ppublish
Résumé
The aim of this study is to analyze postoperative adverse events (AE) in relation to acute primary testicular failure after radiotherapy (RT) for rectal cancer. This relation was assessed in 104 men, included in a previous prospective cohort study of men treated with surgical resection of the rectum for rectal cancer stage I-III. Postoperative AE were graded according to Clavien-Dindo (2004). Grade 3 or more was set as cut-off for severe postoperative AE. The impact of primary testicular failure on postoperative AE was related to the cumulative mean testicular dose (TD) and the change in Testosterone (T) and Luteinizing hormone (LH) sampled at baseline and after RT. Twenty-six study participants (25%) had severe postoperative AE. Baseline characteristics and endocrine testicular function did not differ significantly between groups with (AE+) and without severe postoperative AE (AE-). After RT, the LH/T-ratio was higher in AE+, 0.603 (0.2-2.5) vs 0.452 (0.127-5.926) (p = 0.035). The longitudinal regression analysis showed that preoperative change in T (OR 0.844, 95% CI 0.720-0.990, p = 0.034), LH/T-ratio (OR 2.020, 95% CI 1.010-4.039, p = 0.047) and low T (<8 nmol/L, OR 2.605, 95 CI 0.951-7.139, p = 0.063) were related to severe postoperative AE. Preoperative decline in T due to primary testicular failure induced by preoperative RT could be a risk factor regarding short-term outcome of surgery in men with rectal cancer.
Identifiants
pubmed: 31350073
pii: S0748-7983(19)30581-5
doi: 10.1016/j.ejso.2019.07.023
pmc: PMC6944766
mid: NIHMS1535556
pii:
doi:
Substances chimiques
Biomarkers
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
98-104Subventions
Organisme : NIA NIH HHS
ID : R43 AG045011
Pays : United States
Organisme : NIA NIH HHS
ID : R44 AG045011
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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