Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8

Animals CD8-Positive T-Lymphocytes / immunology Carcinogenesis Cell Differentiation Fatty Acids / metabolism Forkhead Transcription Factors / genetics Immune Evasion Interferon-gamma / metabolism Macrophages / immunology Melanoma / immunology Melanoma, Experimental Mice Mice, Inbred C57BL Mice, Knockout Neoplasms, Experimental / immunology Neuropilin-1 / genetics Sterol Regulatory Element Binding Protein 1 / metabolism T-Lymphocytes, Regulatory / immunology Th2 Cells / immunology Tumor Microenvironment
CD8(+) T cell-derived interferon-γ Treg cells tumor-promoting macrophages

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
20 08 2019
Historique:
received: 04 05 2018
revised: 19 04 2019
accepted: 20 06 2019
pubmed: 28 7 2019
medline: 18 12 2019
entrez: 28 7 2019
Statut: ppublish

Résumé

Regulatory T (Treg) cells are crucial for immune homeostasis, but they also contribute to tumor immune evasion by promoting a suppressive tumor microenvironment (TME). Mice with Treg cell-restricted Neuropilin-1 deficiency show tumor resistance while maintaining peripheral immune homeostasis, thereby providing a controlled system to interrogate the impact of intratumoral Treg cells on the TME. Using this and other genetic models, we showed that Treg cells shaped the transcriptional landscape across multiple tumor-infiltrating immune cell types. Treg cells suppressed CD8

Identifiants

DOI: 10.1016/j.immuni.2019.06.017 PMID: 31350177 PMC: PMC6703933
pubmed: 31350177
pii: S1074-7613(19)30287-0
doi: 10.1016/j.immuni.2019.06.017
pmc: PMC6703933
mid: NIHMS1535261
pii:
doi:

Substances chimiques

Fatty Acids 0
Forkhead Transcription Factors 0
Foxp3 protein, mouse 0
Sterol Regulatory Element Binding Protein 1 0
Neuropilin-1 144713-63-3
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

381-397.e6

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI091977
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NIH HHS
ID : S10 OD019942
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Organisme : NIH HHS
ID : S10 OD011925
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203689
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Références

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Auteurs

Chang Liu (C)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Maria Chikina (M)

Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Rahul Deshpande (R)

Health Sciences Metabolomics and Lipidomics Core, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Ashley V Menk (AV)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.

Ting Wang (T)

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.

Tracy Tabib (T)

Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Erin A Brunazzi (EA)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Kate M Vignali (KM)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Ming Sun (M)

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Donna B Stolz (DB)

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Robert A Lafyatis (RA)

Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Wei Chen (W)

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.

Greg M Delgoffe (GM)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.

Creg J Workman (CJ)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Stacy G Wendell (SG)

Health Sciences Metabolomics and Lipidomics Core, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pharmacology and Chemical Biology, Clinical Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Dario A A Vignali (DAA)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA. Electronic address: dvignali@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Lipides › Acides gras › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Échappement immunitaire › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Mélanome expérimental › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Neuropilines › Neuropiline 1 › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Protéine-1 de liaison à l'élément de régulation des stérols › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › Treg Cells Promote the SREBP1-Dependent...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Treg Cells Promote the SREBP1-Dependent...