The influence of Echinacea purpurea leaf microbiota on chicoric acid level.
Antineoplastic Agents, Phytogenic
/ metabolism
Biological Therapy
/ methods
Caffeic Acids
/ metabolism
Drug Discovery
Echinacea
/ metabolism
Host-Pathogen Interactions
Humans
Inhibitory Concentration 50
L-Lactate Dehydrogenase
/ antagonists & inhibitors
Microbiota
Neoplasms
/ drug therapy
Plant Extracts
Plant Leaves
/ metabolism
Plants, Medicinal
Succinates
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 07 2019
26 07 2019
Historique:
received:
12
09
2018
accepted:
16
07
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
11
11
2020
Statut:
epublish
Résumé
The controversial anti-proliferative effects of Echinacea purpurea (L.) Moench (Asteraceae) might be related to different plant metabolites contained in plant samples, extracts and products. The influence of bacterial endophytes on the synthesis of bioactive compounds in the medicinal plants has been previously demonstrated but there are only few studies addressing anticancer effects and mechanisms of E. purpurea extracts following endophytic colonization. The present study aimed to test and compare the lactate dehydrogenase (LDH) inhibition potential of n-hexane and methanol extracts from in vitro endophyte non-inoculated and inoculated E. purpurea plants. An in vitro model was previously set up to perform the infection of axenic E. purpurea plants with bacterial endophytic strains isolated from E. purpurea aerial part. Only methanol extracts showed LDH5 inhibition, in particular the richest in chicoric acid and most strongly inhibiting extract was obtained from inoculated stem and leaves of E. purpurea (IC
Identifiants
pubmed: 31350520
doi: 10.1038/s41598-019-47329-8
pii: 10.1038/s41598-019-47329-8
pmc: PMC6659708
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Caffeic Acids
0
Plant Extracts
0
Succinates
0
L-Lactate Dehydrogenase
EC 1.1.1.27
chicoric acid
S4YY3V8YHD
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10897Références
Planta Med. 2006 Dec;72(15):1407-14
pubmed: 17054043
Planta Med. 2002 Jun;68(6):572-4
pubmed: 12094312
Future Med Chem. 2013 Oct;5(16):1967-91
pubmed: 24175747
Res Microbiol. 2017 Apr;168(3):293-305
pubmed: 27884784
J Agric Food Chem. 2009 Sep 9;57(17):7907-11
pubmed: 19663425
Sheng Wu Gong Cheng Xue Bao. 2006 Jan;22(1):1-6
pubmed: 16572833
Microbes Infect. 2003 May;5(6):535-44
pubmed: 12758283
J Agric Food Chem. 2012 Dec 12;60(49):12131-41
pubmed: 23181941
J Nutr Biochem. 2010 Nov;21(11):1045-59
pubmed: 20005088
Planta Med. 2006 Feb;72(3):248-54
pubmed: 16534730
Microb Pathog. 2015 May;82:50-9
pubmed: 25865953
J Nat Prod. 2017 Jul 28;80(7):2077-2087
pubmed: 28692289
J Agric Food Chem. 2011 Oct 12;59(19):10425-34
pubmed: 21830789
Int Microbiol. 2014 Sep;17(3):165-74
pubmed: 26419456
Adv Ther. 2015 Mar;32(3):187-200
pubmed: 25784510
Bioorg Med Chem Lett. 2013 Oct 15;23(20):5533-9
pubmed: 24012183
European J Med Plants. 2013;3(4):603-615
pubmed: 24478981
J Ethnopharmacol. 2012 Oct 11;143(3):914-9
pubmed: 22971663
J Comput Chem. 2009 Dec;30(16):2785-91
pubmed: 19399780
Biomed Chromatogr. 2010 Jan;24(1):20-8
pubmed: 19629960
J Agric Food Chem. 2007 Jul 11;55(14):5689-96
pubmed: 17579437
Sci Rep. 2017 Dec 5;7(1):16924
pubmed: 29208923
Bioorg Chem. 2014 Feb;52:16-23
pubmed: 24291035
Phytochemistry. 2015 Aug;116:262-268
pubmed: 25890391
J Enzyme Inhib Med Chem. 2017 Dec;32(1):1240-1252
pubmed: 28936880
J Chromatogr A. 2006 Jan 27;1103(2):219-28
pubmed: 16298376
Plant Cell Rep. 2012 Feb;31(2):361-7
pubmed: 22009052
Bioorg Med Chem Lett. 2013 Dec 15;23(24):6923-7
pubmed: 24200808
Phytochem Anal. 2005 Mar-Apr;16(2):77-85
pubmed: 15881113
Anal Bioanal Chem. 2010 Jul;397(5):1883-92
pubmed: 20467727
Phytother Res. 2018 Sep;32(9):1653-1663
pubmed: 29749084
Planta Med. 2017 Nov;83(17):1313-1320
pubmed: 28437805
Biotechnol Adv. 2012 Nov-Dec;30(6):1425-31
pubmed: 22445787
Front Microbiol. 2016 Jun 09;7:906
pubmed: 27375610
Appl Microbiol Biotechnol. 2014 Sep;98(18):7707-17
pubmed: 25077780
Front Chem. 2013 Dec 31;1:40
pubmed: 24790967
J Pharm Pharmacol. 2005 Aug;57(8):929-54
pubmed: 16102249
ChemMedChem. 2012 Feb 6;7(2):311-7
pubmed: 22052811
J Agric Food Chem. 2004 Jun 30;52(13):4090-6
pubmed: 15212452
Microbiol Res. 2017 Mar;196:34-43
pubmed: 28164789
HortScience. 2005 Aug;40(5):1239-1242
pubmed: 16429598