Pt-Fe ferrocenyl compounds with hydroxyquinoline ligands show selective cytotoxicity on highly proliferative cells.
Animals
Antineoplastic Agents
/ chemical synthesis
Cell Line
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cricetulus
Ferrous Compounds
/ chemistry
Humans
Hydroxyquinolines
/ chemistry
Iron
/ chemistry
Macrophages
/ drug effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Molecular Structure
Platinum
/ chemistry
Reactive Oxygen Species
/ metabolism
Trypanosoma brucei brucei
/ drug effects
X-Ray Diffraction
Anti-proliferative
Cancer cells
Ferrocenyl compounds
Hydroxyquinoline derivatives
Platinum
Trypanosoma brucei
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
13
05
2019
revised:
12
07
2019
accepted:
14
07
2019
pubmed:
28
7
2019
medline:
14
7
2020
entrez:
28
7
2019
Statut:
ppublish
Résumé
Searching for a more effective chemotherapy for the treatment of Human African trypanosomiasis, the disease caused by the parasite Trypanosoma brucei, and cancer, in the current work five new [Pt
Identifiants
pubmed: 31351379
pii: S0162-0134(19)30280-6
doi: 10.1016/j.jinorgbio.2019.110779
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Ferrous Compounds
0
Hydroxyquinolines
0
Reactive Oxygen Species
0
Platinum
49DFR088MY
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110779Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.