Effect of heart rate on the pharmacokinetics of fentanyl in dogs anesthetized with isoflurane and hydromorphone.
Adjuvants, Anesthesia
/ administration & dosage
Analgesics, Opioid
/ administration & dosage
Anesthetics, Inhalation
/ administration & dosage
Animals
Cross-Over Studies
Dogs
Drug Interactions
Fentanyl
/ administration & dosage
Heart Rate
/ drug effects
Hydromorphone
/ administration & dosage
Isoflurane
/ administration & dosage
Male
cardiac output
dog
fentanyl
heart rate
isoflurane
pharmacokinetics
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
30
01
2019
revised:
07
06
2019
accepted:
09
06
2019
pubmed:
30
7
2019
medline:
13
3
2020
entrez:
30
7
2019
Statut:
ppublish
Résumé
To compare the pharmacokinetics of fentanyl at lower (LHR) or higher heart rate (HHR) in dogs anesthetized with isoflurane. Prospective, randomized, crossover controlled trial. A group of six healthy 13-month-old male Beagle dogs weighing 9.9 ± 0.7 kg (mean ± standard deviation). Dogs were allocated to two treatments: LHR (HR: 45-75 beats minute A three-compartment model best fitted the changes in plasma fentanyl concentration. Clearance (CL; mL minute The increase in HR and the resultant improvement in cardiac output increased fentanyl CL and volume of distribution, which resulted in a decrease in plasma fentanyl concentration in isoflurane-anesthetized dogs.
Identifiants
pubmed: 31353195
pii: S1467-2987(19)30169-2
doi: 10.1016/j.vaa.2019.06.005
pii:
doi:
Substances chimiques
Adjuvants, Anesthesia
0
Analgesics, Opioid
0
Anesthetics, Inhalation
0
Isoflurane
CYS9AKD70P
Hydromorphone
Q812464R06
Fentanyl
UF599785JZ
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
736-744Informations de copyright
Copyright © 2019 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.