Identification and evaluation of quercetin as a potential inhibitor of naphthoate synthase from Enterococcus faecalis.
E. faecalis naphthoate synthase
docking
in silico modeling
preliminary structural studies
spectrofluorimetric binding studies
Journal
Journal of molecular recognition : JMR
ISSN: 1099-1352
Titre abrégé: J Mol Recognit
Pays: England
ID NLM: 9004580
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
12
03
2019
revised:
29
05
2019
accepted:
07
06
2019
pubmed:
30
7
2019
medline:
20
6
2020
entrez:
30
7
2019
Statut:
ppublish
Résumé
Enterococcus faecalis is a gram-positive, rod-shape bacteria responsible for around 65% to 80% of all enterococcal nosocomial infections. It is multidrug resistant (MDR) bacterium resistant to most of the first-line antibiotics. Due to the emergence of MDR strains, there is an urgent need to find novel targets to develop new antibacterial drugs against E. faecalis. In this regard, we have identified naphthoate synthase (1,4-dihydroxy-2-naphthoyl-CoA synthase, EC: 4.1.3.36; DHNS) as an anti-E. faecalis target, as it is an essential enzyme for menaquinone (vitamin K
Substances chimiques
Enzyme Inhibitors
0
Quercetin
9IKM0I5T1E
Hydro-Lyases
EC 4.2.1.-
naphthoate synthetase
EC 4.2.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2802Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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