Escherichia coli Nissle 1917 Protects Intestinal Barrier Function by Inhibiting NF-
Animals
Blotting, Western
Caco-2 Cells
Escherichia coli
/ physiology
Humans
Intestinal Mucosa
/ metabolism
Male
Mice
Mice, Inbred C57BL
NF-kappa B
/ metabolism
Occludin
/ metabolism
Phosphorylation
/ physiology
Sepsis
/ metabolism
Signal Transduction
Tight Junction Proteins
/ metabolism
Tight Junctions
/ metabolism
Transcription Factor RelA
/ metabolism
Zonula Occludens-1 Protein
/ metabolism
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
02
2019
revised:
17
05
2019
accepted:
29
05
2019
entrez:
30
7
2019
pubmed:
30
7
2019
medline:
14
1
2020
Statut:
epublish
Résumé
Escherichia coli Nissle 1917 (EcN), a kind of probiotic, has been reported to have a protective effect on the intestinal barrier function and can ameliorate certain gastrointestinal disorders. In this study, the potential protective effect of EcN on the intestinal barrier function in a septic mouse model induced by cecal ligation and puncture (CLP) operation was investigated. FITC-Dextran 4,000 Da (FD-4) flux and the expression levels of tight junction (TJ) proteins were measured to evaluate the protective effect of EcN on the intestinal barrier function. Then, Caco-2 monolayers were utilized to further investigate the protective effect of the EcN supernatant (EcN
Identifiants
pubmed: 31354386
doi: 10.1155/2019/5796491
pmc: PMC6636522
doi:
Substances chimiques
NF-kappa B
0
Occludin
0
TJP1 protein, human
0
Tight Junction Proteins
0
Transcription Factor RelA
0
Zonula Occludens-1 Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5796491Références
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