Amplitude-integrated EEG in infants with neonatal abstinence syndrome.
Adult
Brain
/ blood supply
Electroencephalography
/ instrumentation
Female
Gestational Age
Guidelines as Topic
Humans
Infant, Newborn
Infant, Premature
Male
Monitoring, Physiologic
Neonatal Abstinence Syndrome
/ diagnostic imaging
Pilot Projects
Pregnancy
Prospective Studies
Sleep Disorders, Circadian Rhythm
/ diagnostic imaging
Journal
Journal of neonatal-perinatal medicine
ISSN: 1878-4429
Titre abrégé: J Neonatal Perinatal Med
Pays: Netherlands
ID NLM: 101468335
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
30
7
2019
medline:
22
7
2020
entrez:
30
7
2019
Statut:
ppublish
Résumé
To describe amplitude-integrated encephalogram (aEEG) characteristics of neonates with neonatal abstinence syndrome (NAS). This is a prospective observational study. Newborns exposed to prenatal opioids and their gestational matched controls were included. A single-channel aEEG was obtained using Olympic 6000 CFM monitor. The background activity (continuous/discontinuous), the amplitudes (μV) and the presence of sleep-wake cycle (SWC) were documented. A total of 59 infants, 23 with NAS and 36 controls were enrolled. All aEEG were completed within 48 hours of life prior to initiation of treatment. Birth weight and gestational age were similar in both groups. An aEEG was abnormal (discontinuous pattern and/or absent SWC) in 78 % (18/23) of infants with NAS versus only 25% in control group (9/36), [OR 10.8, CI (2.7-46.5) P < 0.001]. 61% of infants with NAS had discontinuous pattern [OR 7.8, CI (2-32) P = 0.001] and 39% had absence of sleep-wake cycle [OR 7.1, CI (1.4-39.4) P = 0.007]. A majority of infants with NAS have abnormal aEEG activity.
Sections du résumé
BACKGROUND
BACKGROUND
To describe amplitude-integrated encephalogram (aEEG) characteristics of neonates with neonatal abstinence syndrome (NAS).
METHODS
METHODS
This is a prospective observational study. Newborns exposed to prenatal opioids and their gestational matched controls were included. A single-channel aEEG was obtained using Olympic 6000 CFM monitor. The background activity (continuous/discontinuous), the amplitudes (μV) and the presence of sleep-wake cycle (SWC) were documented.
RESULTS
RESULTS
A total of 59 infants, 23 with NAS and 36 controls were enrolled. All aEEG were completed within 48 hours of life prior to initiation of treatment. Birth weight and gestational age were similar in both groups. An aEEG was abnormal (discontinuous pattern and/or absent SWC) in 78 % (18/23) of infants with NAS versus only 25% in control group (9/36), [OR 10.8, CI (2.7-46.5) P < 0.001]. 61% of infants with NAS had discontinuous pattern [OR 7.8, CI (2-32) P = 0.001] and 39% had absence of sleep-wake cycle [OR 7.1, CI (1.4-39.4) P = 0.007].
CONCLUSIONS
CONCLUSIONS
A majority of infants with NAS have abnormal aEEG activity.
Identifiants
pubmed: 31356218
pii: NPM1834
doi: 10.3233/NPM-1834
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM