The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

Cell Proliferation / genetics Cell Transformation, Neoplastic / genetics Cellular Reprogramming / genetics Free Radicals / metabolism Glycolysis / genetics Humans Mitochondria / genetics Neoplasms / genetics Oxidative Phosphorylation Sodium-Hydrogen Exchanger 1 / genetics Tumor Microenvironment / genetics
Na+/H+ exchanger pH and Warburg metabolism pH and cancer proton transport in cancer tumor metabolic microenvironment

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
28 07 2019
Historique:
received: 29 06 2019
revised: 23 07 2019
accepted: 25 07 2019
entrez: 31 7 2019
pubmed: 31 7 2019
medline: 10 1 2020
Statut: epublish

Résumé

Cancer cells have an unusual regulation of hydrogen ion dynamics that are driven by poor vascularity perfusion, regional hypoxia, and increased glycolysis. All these forces synergize/orchestrate together to create extracellular acidity and intracellular alkalinity. Precisely, they lead to extracellular pH (pH

Identifiants

DOI: 10.3390/ijms20153694 PMID: 31357694 PMC: PMC6696090
pubmed: 31357694
pii: ijms20153694
doi: 10.3390/ijms20153694
pmc: PMC6696090
pii:
doi:

Substances chimiques

Free Radicals 0
Sodium-Hydrogen Exchanger 1 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Références

Science. 1999 Mar 5;283(5407):1476-81
pubmed: 10066161
J Biol Chem. 2000 Feb 25;275(8):5361-9
pubmed: 10681510
Int J Radiat Biol. 2000 May;76(5):589-605
pubmed: 10866281
FASEB J. 2000 Nov;14(14):2185-97
pubmed: 11053239
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14608-13
pubmed: 11121063
J Biol Chem. 2002 Sep 27;277(39):36085-91
pubmed: 12138085
J Clin Invest. 2002 Oct;110(8):1185-90
pubmed: 12393854
Philos Trans R Soc Lond B Biol Sci. 2003 Jan 29;358(1429):165-77; discussion 177-9
pubmed: 12594925
Biochem Biophys Res Commun. 2003 Apr 25;304(1):130-5
pubmed: 12705896
Science. 1956 Aug 10;124(3215):269-70
pubmed: 13351639
BMC Genomics. 2004 Jul 16;5(1):46
pubmed: 15257760
Biochem J. 1992 Mar 15;282 ( Pt 3):797-805
pubmed: 1554363
Prostate. 2005 Jun 1;63(4):316-23
pubmed: 15599942
Biochim Biophys Acta. 2005 Sep 25;1756(1):1-24
pubmed: 16099110
Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):554-63
pubmed: 16144692
Nat Rev Cancer. 2005 Oct;5(10):786-95
pubmed: 16175178
Bioinformatics. 2005 Sep 1;21 Suppl 2:ii144-50
pubmed: 16204094
Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1237-44
pubmed: 16434551
Biol Direct. 2006 Mar 23;1:8
pubmed: 16556314
J Nihon Univ Sch Dent. 1991 Jun;33(2):81-90
pubmed: 1658253
Nat Rev Cancer. 2006 Dec;6(12):924-35
pubmed: 17109012
Mol Biol Cell. 2007 May;18(5):1768-80
pubmed: 17332506
Curr Top Med Chem. 2007;7(9):825-33
pubmed: 17504127
Cancer Res. 2007 Nov 15;67(22):10627-30
pubmed: 18006801
Clin Exp Metastasis. 2008;25(4):411-25
pubmed: 18301995
Curr Pharm Des. 2008;14(7):603-14
pubmed: 18336305
BMC Med. 2008 Apr 28;6:11
pubmed: 18442412
Neoplasia. 2008 May;10(5):481-8
pubmed: 18472965
Eur J Pharmacol. 2008 Jun 10;587(1-3):104-11
pubmed: 18486127
J Clin Invest. 2008 Dec;118(12):3930-42
pubmed: 19033663
PLoS Genet. 2008 Dec;4(12):e1000293
pubmed: 19057672
Br J Cancer. 1991 Sep;64(3):425-7
pubmed: 1911181
Br J Cancer. 1991 Oct;64(4):663-70
pubmed: 1911214
Cancer Res. 2009 Jan 1;69(1):358-68
pubmed: 19118021
Anticancer Res. 2009 Jun;29(6):2127-36
pubmed: 19528473
Cell Cycle. 2009 Dec;8(23):3984-4001
pubmed: 19923890
J Immunol. 2010 Feb 1;184(3):1200-9
pubmed: 20026743
FASEB J. 2010 Oct;24(10):3903-15
pubmed: 20547664
J Transl Med. 2010 Jun 15;8:57
pubmed: 20550689
J Theor Biol. 2010 Dec 7;267(3):454-60
pubmed: 20699102
J Theor Biol. 2010 Dec 7;267(3):461-70
pubmed: 20816684
Trends Cell Biol. 2010 Dec;20(12):734-42
pubmed: 20817460
PLoS Genet. 2010 Sep 02;6(9):e1001093
pubmed: 20844768
Med Hypotheses. 2011 May;76(5):761-2
pubmed: 21316865
J Biol Chem. 2011 Apr 22;286(16):13815-26
pubmed: 21345798
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
NMR Biomed. 2011 Jul;24(6):582-91
pubmed: 21387439
PLoS One. 2011 Feb 24;6(2):e17416
pubmed: 21390324
Exp Oncol. 2010 Sep;32(3):125-7
pubmed: 21403604
Nat Rev Cancer. 2011 Aug 11;11(9):671-7
pubmed: 21833026
Histol Histopathol. 2011 Oct;26(10):1279-86
pubmed: 21870331
Nat Rev Drug Discov. 2011 Sep 16;10(10):767-77
pubmed: 21921921
Cancer Res. 2012 Jan 15;72(2):491-502
pubmed: 22135092
Oncotarget. 2012 Jan;3(1):84-97
pubmed: 22289741
Curr Pharm Des. 2012;18(10):1345-71
pubmed: 22360557
J Bioenerg Biomembr. 2012 Feb;44(1):127-39
pubmed: 22407107
PLoS One. 2012;7(3):e33418
pubmed: 22428047
J Gen Physiol. 2012 Jun;139(6):415-23
pubmed: 22641636
Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a011403
pubmed: 22952398
Curr Top Membr. 2012;70:275-311
pubmed: 23177990
Nat Genet. 2013 Jan;45(1):104-8
pubmed: 23202129
Chem Biol Drug Des. 2013 Jan;81(1):85-101
pubmed: 23253131
Cell. 2012 Dec 21;151(7):1406-16
pubmed: 23260134
Cancer Res. 2013 Mar 1;73(5):1524-35
pubmed: 23288510
Evol Appl. 2013 Jan;6(1):46-53
pubmed: 23396634
Pain Res Treat. 2013;2013:217864
pubmed: 23431433
Annu Rev Biophys. 2013;42:289-314
pubmed: 23451893
Cell Cycle. 2013 May 1;12(9):1371-84
pubmed: 23574725
Biol Chem. 2013 Oct;394(10):1343-8
pubmed: 23851572
J Korean Med Sci. 2013 Aug;28(8):1238-43
pubmed: 23960454
Nat Rev Cancer. 2013 Sep;13(9):611-23
pubmed: 23969692
Cancer Lett. 2014 Jan 1;342(1):150-8
pubmed: 24012639
J Transl Med. 2013 Nov 06;11:282
pubmed: 24195657
Cancers (Basel). 2011 Jan 20;3(1):408-14
pubmed: 24310355
Cancers (Basel). 2011 Jul 22;3(3):3002-17
pubmed: 24310356
BMC Cancer. 2014 Apr 23;14:279
pubmed: 24755315
Sci Rep. 2014 May 13;4:4927
pubmed: 24820099
Semin Cancer Biol. 2015 Apr;31:65-75
pubmed: 25117005
Oncoscience. 2014 Dec 18;1(12):777-802
pubmed: 25621294
J Mol Med (Berl). 2016 Feb;94(2):155-71
pubmed: 26099350
Recent Pat Anticancer Drug Discov. 2015;10(3):244-58
pubmed: 26152150
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec;159(4):519-26
pubmed: 26725705
Pancreas. 2016 Aug;45(7):1036-47
pubmed: 26765963
J Enzyme Inhib Med Chem. 2016 Dec;31(6):859-66
pubmed: 26864256
Biochim Biophys Acta. 2016 Oct;1863(10):2465-80
pubmed: 26944480
Am J Cancer Res. 2016 Mar 15;6(4):859-75
pubmed: 27186436
Sci Rep. 2016 Jun 15;6:27803
pubmed: 27302093
Sci Adv. 2016 May 27;2(5):e1600200
pubmed: 27386546
Skin Pharmacol Physiol. 2016;29(4):204-9
pubmed: 27441370
PLoS One. 2016 Aug 01;11(8):e0159529
pubmed: 27479079
Nat Rev Cancer. 2016 Nov;16(11):732-749
pubmed: 27658529
Anticancer Agents Med Chem. 2017;17(2):164-170
pubmed: 27804847
Semin Cancer Biol. 2017 Apr;43:5-16
pubmed: 28007556
Oncotarget. 2017 Feb 7;8(6):10225-10237
pubmed: 28055960
Semin Cancer Biol. 2017 Apr;43:17-34
pubmed: 28065864
Semin Cancer Biol. 2017 Apr;43:111-118
pubmed: 28088584
Semin Cancer Biol. 2017 Apr;43:66-73
pubmed: 28137473
Semin Cancer Biol. 2017 Apr;43:157-179
pubmed: 28193528
J Cell Sci. 2017 Feb 15;130(4):663-669
pubmed: 28202602
Cell Rep. 2017 Feb 28;18(9):2228-2242
pubmed: 28249167
Wound Repair Regen. 2017 Apr;25(2):260-269
pubmed: 28370923
Sci Rep. 2017 Aug 21;7(1):8911
pubmed: 28827680
Adv Exp Med Biol. 2017;1035:105-119
pubmed: 29080133
Oncoscience. 2018 Jun 24;5(5-6):132-133
pubmed: 30035164
Nat Commun. 2018 Jul 31;9(1):2997
pubmed: 30065243
Oxid Med Cell Longev. 2018 Aug 5;2018:2018306
pubmed: 30154947
J Enzyme Inhib Med Chem. 2019 Dec;34(1):117-123
pubmed: 30362384
Mol Cell Biol. 1987 May;7(5):1984-8
pubmed: 3037340
Gene. 1987;54(1):147-53
pubmed: 3038697
Sci Rep. 2018 Nov 20;8(1):17094
pubmed: 30459440
J Biol Chem. 1973 Dec 10;248(23):8095-106
pubmed: 4584823
Clin Exp Metastasis. 1996 Mar;14(2):176-86
pubmed: 8605731
Cancer Metastasis Rev. 1995 Dec;14(4):323-38
pubmed: 8821093
Cancer Res. 1996 Dec 15;56(24):5754-7
pubmed: 8971187
Circ Res. 1997 Mar;80(3):400-7
pubmed: 9048661
Clin Exp Metastasis. 1997 Mar;15(2):140-50
pubmed: 9062390
Pharmacol Ther. 1997;74(1):1-20
pubmed: 9336012

Auteurs

Rosa Angela Cardone (RA)

Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari, 90126 Bari, Italy.

Khalid Omer Alfarouk (KO)

Alfarouk Biomedical Research LLC, Tampa, FL 33617, USA. Alfarouk@Hala-Alfarouk.org.
Hala Alfarouk Cancer Center, Khartoum 11112, Sudan. Alfarouk@Hala-Alfarouk.org.
American Biosciences Inc., New York, NY 10913, USA. Alfarouk@Hala-Alfarouk.org.

Robert L Elliott (RL)

The Sallie A. Burdine Breast Foundation, Baton Rouge, LA 70806, USA.
The Elliott-Elliott-Baucom Breast Cancer Research and Treatment Center, Baton Rouge, LA 70806, USA.

Saad Saaed Alqahtani (SS)

Clinical Pharmacy Department, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

Samrein B M Ahmed (SBM)

College of Medicine, University of Sharjah, Sharjah, UAE.

Ahmed N Aljarbou (AN)

College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.

Maria Raffaella Greco (MR)

Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari, 90126 Bari, Italy.

Stefania Cannone (S)

Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari, 90126 Bari, Italy.

Stephan Joel Reshkin (SJ)

Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari, 90126 Bari, Italy. khaliomer@gmail.com.
ORCID: 0000-0001-9757-5908

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Tumeurs › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphorylation oxydative › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Antiport des ions sodium-hydrogène › Échangeur-1 de sodium-hydrogène › The Role of Sodium Hydrogen Exchanger 1 in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › The Role of Sodium Hydrogen Exchanger 1 in...