Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca
Adjuvants, Immunologic
/ pharmacology
Animals
Calcium
/ metabolism
Cell Membrane
/ physiology
Colforsin
/ pharmacology
Cyclic AMP
/ metabolism
Gene Expression Regulation
/ drug effects
Glucose
/ pharmacology
Guanine Nucleotide Exchange Factors
/ genetics
Membrane Potentials
/ drug effects
Mice
Pancreas
/ cytology
Somatostatin
/ metabolism
Somatostatin-Secreting Cells
/ drug effects
Thapsigargin
/ pharmacology
Journal
The Journal of general physiology
ISSN: 1540-7748
Titre abrégé: J Gen Physiol
Pays: United States
ID NLM: 2985110R
Informations de publication
Date de publication:
02 09 2019
02 09 2019
Historique:
received:
18
02
2019
revised:
11
05
2019
accepted:
09
07
2019
pubmed:
31
7
2019
medline:
5
9
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion (GISS) involves both membrane potential-dependent and -independent pathways. Although glucose-induced electrical activity triggers somatostatin release, the sugar also stimulates GISS via a cAMP-dependent stimulation of CICR and exocytosis of somatostatin. The latter effect is more quantitatively important and in mouse islets depolarized by 70 mM extracellular K
Identifiants
pubmed: 31358556
pii: jgp.201912351
doi: 10.1085/jgp.201912351
pmc: PMC6719402
doi:
Substances chimiques
Adjuvants, Immunologic
0
Guanine Nucleotide Exchange Factors
0
Rapgef4 protein, mouse
0
Colforsin
1F7A44V6OU
Somatostatin
51110-01-1
Thapsigargin
67526-95-8
Cyclic AMP
E0399OZS9N
Glucose
IY9XDZ35W2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1094-1115Subventions
Organisme : Medical Research Council
ID : MC_UU_00014/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/3
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095531/Z/11/Z
Pays : United Kingdom
Informations de copyright
© 2019 Denwood et al.
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