A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.

Amino Acid Sequence Animals Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / blood Autoimmunity / immunology Bacterial Proteins / genetics Epitopes, T-Lymphocyte / genetics Glomerulonephritis / immunology Heymann Nephritis Antigenic Complex / immunology Humans Male Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Peptides / genetics Peroxidase / immunology Plasmids / genetics Staphylococcus aureus / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
29 07 2019
Historique:
received: 27 05 2018
accepted: 26 06 2019
entrez: 31 7 2019
pubmed: 31 7 2019
medline: 3 1 2020
Statut: epublish

Résumé

Autoreactivity to myeloperoxidase (MPO) causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with rapidly progressive glomerulonephritis. Here, we show that a Staphylococcus aureus peptide, homologous to an immunodominant MPO T-cell epitope (MPO

Identifiants

DOI: 10.1038/s41467-019-11255-0 PMID: 31358739 PMC: PMC6662820
pubmed: 31358739
doi: 10.1038/s41467-019-11255-0
pii: 10.1038/s41467-019-11255-0
pmc: PMC6662820
doi:

Substances chimiques

Bacterial Proteins 0
Epitopes, T-Lymphocyte 0
Heymann Nephritis Antigenic Complex 0
Peptides 0
Peroxidase EC 1.11.1.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3392

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

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Auteurs

Joshua D Ooi (JD)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.

Jhih-Hang Jiang (JH)

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, 3800, Australia.
ORCID: 0000-0002-1543-1634

Peter J Eggenhuizen (PJ)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.
ORCID: 0000-0002-7102-3547

Ling L Chua (LL)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.
Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
ORCID: 0000-0002-1315-9489

Mirjan van Timmeren (M)

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.

Khai L Loh (KL)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
ORCID: 0000-0002-2211-2404

Kim M O'Sullivan (KM)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.

Poh Y Gan (PY)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.

Yong Zhong (Y)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.

Kirill Tsyganov (K)

Monash Bioinformatics Platform, Monash University, Clayton, VIC, 3800, Australia.
ORCID: 0000-0002-9195-2626

Lani R Shochet (LR)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.
Department of Nephrology, Monash Health, Clayton, VIC, 3168, Australia.

Jessica Ryan (J)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.
Department of Nephrology, Monash Health, Clayton, VIC, 3168, Australia.

Coen A Stegeman (CA)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.

Lars Fugger (L)

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
ORCID: 0000-0003-2883-3226

Hugh H Reid (HH)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC, 3800, Australia.
ORCID: 0000-0001-6929-5001

Jamie Rossjohn (J)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC, 3800, Australia.
Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, CF14-4XN, UK.
ORCID: 0000-0002-2020-7522

Peter Heeringa (P)

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
ORCID: 0000-0001-8684-763X

Stephen R Holdsworth (SR)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia.
Department of Nephrology, Monash Health, Clayton, VIC, 3168, Australia.

Anton Y Peleg (AY)

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, 3800, Australia.
Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
ORCID: 0000-0002-2296-2126

A Richard Kitching (AR)

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, 3168, Australia. richard.kitching@monash.edu.
Department of Nephrology, Monash Health, Clayton, VIC, 3168, Australia. richard.kitching@monash.edu.
NHMRC Centre for Personalised Immunology, Monash University, Clayton, VIC, 3168, Australia. richard.kitching@monash.edu.
Department of Pediatric Nephrology, Monash Health, Clayton, VIC, 3168, Australia. richard.kitching@monash.edu.
ORCID: 0000-0002-2713-2391

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › A plasmid-encoded peptide from Staphylococcus...
questionsmedicales.fr › Eucaryotes › Animaux › A plasmid-encoded peptide from Staphylococcus...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › A plasmid-encoded peptide from Staphylococcus...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › A plasmid-encoded peptide from Staphylococcus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › A plasmid-encoded peptide from Staphylococcus...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes T › A plasmid-encoded peptide from Staphylococcus...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Glomérulonéphrite › A plasmid-encoded peptide from Staphylococcus...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Complexe antigénique de la néphrite de Heymann › A plasmid-encoded peptide from Staphylococcus...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A plasmid-encoded peptide from Staphylococcus...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › A plasmid-encoded peptide from Staphylococcus...
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questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › A plasmid-encoded peptide from Staphylococcus...