Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1.
Animals
Cell Adhesion Molecules
/ metabolism
Chemokines
/ metabolism
Dendritic Cells
/ immunology
Disease Models, Animal
Dogs
Influenza A virus
/ immunology
Interferon Type I
/ metabolism
Killer Cells, Natural
Lectins, C-Type
/ metabolism
Madin Darby Canine Kidney Cells
Mice
Orthomyxoviridae Infections
/ immunology
Receptors, Cell Surface
/ metabolism
Trachea
/ immunology
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
10
05
2018
accepted:
06
06
2019
pubmed:
31
7
2019
medline:
8
2
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
The early phase of influenza infection occurs in the upper respiratory tract and the trachea, but little is known about the initial events of virus recognition and control of viral dissemination by the immune system. Here, we report that inflammatory dendritic cells (IDCs) are recruited to the trachea shortly after influenza infection through type I interferon-mediated production of the chemokine CCL2. We further show that recruited IDCs express the C-type lectin receptor SIGN-R1, which mediates direct recognition of the virus by interacting with N-linked glycans present in glycoproteins of the virion envelope. Activation of IDCs via SIGN-R1 triggers the production of the chemokines CCL5, CXCL9 and CXCL10, which initiate the recruitment of protective natural killer (NK) cells in the infected trachea. In the absence of SIGN-R1, the recruitment and activation of NK cells is impaired, leading to uncontrolled viral proliferation. In sum, our results provide insight into the orchestration of the early cellular and molecular events involved in immune protection against influenza.
Identifiants
pubmed: 31358982
doi: 10.1038/s41564-019-0506-6
pii: 10.1038/s41564-019-0506-6
pmc: PMC6817362
mid: EMS83327
doi:
Substances chimiques
Cell Adhesion Molecules
0
Chemokines
0
DC-specific ICAM-3 grabbing nonintegrin
0
Interferon Type I
0
Lectins, C-Type
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1930-1940Subventions
Organisme : Swiss National Science Foundation
ID : 145038
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 148183
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 176124
Pays : Switzerland
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