Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors.

Guanidines / chemical synthesis Heterocyclic Compounds / chemical synthesis Histamine Agonists / chemical synthesis Humans Ligands Radioligand Assay Receptors, Histamine / metabolism Structure-Activity Relationship
UR-PI376 aliphatic heterocycles bioisosteres cyanoguanidines histamine receptors

Journal

Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167

Informations de publication

Date de publication:
Sep 2019
Historique:
received: 04 04 2019
revised: 03 05 2019
accepted: 22 05 2019
pubmed: 31 7 2019
medline: 25 1 2020
entrez: 31 7 2019
Statut: ppublish

Résumé

Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR-PI376, as highly potent agonists at the human histamine H

Identifiants

DOI: 10.1002/ardp.201900107 PMID: 31359502
pubmed: 31359502
doi: 10.1002/ardp.201900107
doi:

Substances chimiques

Guanidines 0
Heterocyclic Compounds 0
Histamine Agonists 0
Ligands 0
Receptors, Histamine 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1900107

Informations de copyright

© 2019 Deutsche Pharmazeutische Gesellschaft.

Auteurs

Beatrice Soliman (B)

Institute of Pharmacy, University of Regensburg, Regensburg, Germany.
Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.

Ning Wang (N)

Institute of Pharmacy, University of Regensburg, Regensburg, Germany.

Giuseppe Zagotto (G)

Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
ORCID: 0000-0001-7053-4196

Steffen Pockes (S)

Institute of Pharmacy, University of Regensburg, Regensburg, Germany.
ORCID: 0000-0002-2211-9868

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Synthesis and biological evaluation of...
questionsmedicales.fr › Composés hétérocycliques › Synthesis and biological evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents histaminiques › Agonistes histaminergiques › Synthesis and biological evaluation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and biological evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Synthesis and biological evaluation of...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Dosage par compétition › Synthesis and biological evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs histaminergiques › Synthesis and biological evaluation of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis and biological evaluation of...