Periocular necrotizing soft tissue infection in Greater Copenhagen.
Adult
Aged
Aged, 80 and over
B-Lymphocytes
/ pathology
Denmark
/ epidemiology
Eye Infections, Bacterial
/ epidemiology
Fasciitis, Necrotizing
/ epidemiology
Female
Granulocytes
/ pathology
Histiocytes
/ pathology
Humans
Macrophages
/ parasitology
Male
Middle Aged
Soft Tissue Infections
/ epidemiology
Staphylococcal Infections
/ epidemiology
Streptococcal Infections
/ epidemiology
T-Lymphocytes
/ pathology
immunohistochemistry
necrotizing fasciitis
periocular
skin
streptococcus
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
17
04
2019
accepted:
07
07
2019
pubmed:
31
7
2019
medline:
23
1
2021
entrez:
31
7
2019
Statut:
ppublish
Résumé
Necrotizing soft tissue infection, also known as necrotizing fasciitis (NF), is a fast-spreading life-threatening infection that most commonly affects the lower limbs, groin, or abdomen. Periocular necrotizing fasciitis (PNF) is rare. Limited data exist on PNF immune cell subset; hence, this study aims to determine the representation of immune cell subsets in patients diagnosed with PNF using immunohistochemical stainings. All patients diagnosed with PNF at Copenhagen University Hospital from 2008 to 2018 were included. Their electronic medical records and pathology reports were assessed, and available tissue specimens were reviewed and stained with monoclonal antibodies for CD1a The specimens were characterized by acute inflammation and necrosis of the fascia, while striated muscle involvement was less frequent. Haemolytic group A streptococci and Staphylococcus aureus were identified and mainly located in the deep dermis and subcutis in close relation to the fascia. Only few areas harboured both bacteria and inflammatory cells. Granulocytes, histiocytes and CD44 The immune cell subsets found in this study of PNF were consistent with those identified in the literature on NF in other anatomical locations. This study concludes that immune cells are abundant and exhibit a typical pattern in PNF.
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
207-212Informations de copyright
© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
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