Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available.


Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
12 2019
Historique:
pubmed: 31 7 2019
medline: 20 9 2020
entrez: 31 7 2019
Statut: ppublish

Résumé

Ruxolitinib was recently approved for the treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea based on data from the RESPONSE studies. This phase 3b, Expanded Treatment Protocol study (NCT02292446) of ruxolitinib for hydroxyurea-resistant/intolerant patients with polycythemia vera (

Identifiants

pubmed: 31359808
doi: 10.1080/10428194.2019.1636985
doi:

Substances chimiques

Antineoplastic Agents 0
Nitriles 0
Pyrazoles 0
Pyrimidines 0
ruxolitinib 82S8X8XX8H
Hydroxyurea X6Q56QN5QC

Types de publication

Clinical Trial, Phase III Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

3493-3502

Auteurs

Lynda Foltz (L)

St. Paul's Hospital, University of British Columbia, Vancouver, Canada.

Gian-Matteo Pica (GM)

Service of Hematology, Centre Hospitalier Métropole Savoie, Chambery, France.

Hacene Zerazhi (H)

Clinical Hematology, Avignon Hospital, Avignon, France.

Jan Van Droogenbroeck (J)

Department of Hematology, AZ St. Jan AV, Brugge, Belgium.

Sorin Visanica (S)

Service Hématologie, Hôpital Belle Isle, HP Metz, France.

Enrique Báez de la Fuente (E)

OCA Hospital, Monterrey, México.

Brian Leber (B)

Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Canada.

Antonio Medina de Almeida (AM)

Hospital da Luz, Lisbon, Portugal.

Dana Ranta (D)

Centre Hospitalier Universitaire, Nancy, France.

Jean-Jacques Kiladjian (JJ)

Centre d'Investigations Cliniques, AP-HP, Hôpital Saint-Louis, Université Paris Diderot, INSERM CIC 1427, Paris, France.

Linda Chrit (L)

Novartis AG, Basel, Switzerland.

Albert Kandra (A)

Novartis AG, Basel, Switzerland.

Juliane Morando (J)

Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

Timothy Devos (T)

Department of Hematology, University Hospitals Leuven, Leuven, Belgium.
Laboratory of Experimental Transplantation, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

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Classifications MeSH