Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia.

Animals Cinnamates / pharmacology Disease Models, Animal Eukaryotic Initiation Factor-2 / metabolism Female Fertility / drug effects Galactosemias / complications Infertility, Female / drug therapy Mice Ovary / drug effects Phosphorylation / drug effects Thiourea / analogs & derivatives Unfolded Protein Response / drug effects
Classic Galactosemia Galactosemic stress Perk branch of the unfolded protein response (UPR) Pi3K/Akt signaling Salubrinal Subfertility

Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 20 02 2019
revised: 15 07 2019
accepted: 23 07 2019
pubmed: 31 7 2019
medline: 27 5 2020
entrez: 31 7 2019
Statut: ppublish

Résumé

Loss of galactose-1 phosphate uridylyltransferase (GALT) activity in humans results in Classic Galactosemia, and the GalT-deficient (GalT

Identifiants

DOI: 10.1016/j.bbadis.2019.07.010 PMID: 31362041 PMC: PMC6751024
pubmed: 31362041
pii: S0925-4439(19)30233-9
doi: 10.1016/j.bbadis.2019.07.010
pmc: PMC6751024
mid: NIHMS1535862
pii:
doi:

Substances chimiques

Cinnamates 0
Eukaryotic Initiation Factor-2 0
salubrinal 0
Thiourea GYV9AM2QAG

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

165516

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD074844
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119540
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

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Auteurs

B Balakrishnan (B)

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States.

A Siddiqi (A)

Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, United States.

J Mella (J)

School of Biological Sciences, University of Utah College of Science, United States.

A Lupo (A)

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States.

E Li (E)

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States.

J Hollien (J)

School of Biological Sciences, University of Utah College of Science, United States.

J Johnson (J)

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Colorado, United States. Electronic address: JOSHUA.2.JOHNSON@UCDENVER.EDU.

K Lai (K)

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, United States. Electronic address: kent.lai@hsc.utah.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Cinnamates › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines ribosomiques › Facteurs initiation chaîne peptidique › Facteurs d'initiation eucaryotes › Facteur-2 d'initiation eucaryote › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Fécondité › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme glucidique › Galactosémies › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Infertilité › Infertilité féminine › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Ovaire › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Métabolisme › Phosphorylation › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiourée › Salubrinal enhances eIF2α phosphorylation and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Réponse aux protéines mal repliées › Salubrinal enhances eIF2α phosphorylation and...